Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer

Andrew J Fritz^{1

2

3}, Kyle T McKay^{2

3

4}, Haley W Greenyer^{1

2

3}, Emory Pacht^{1

2

3}, Rabail H Toor^{1

2

3}, Rahim Ullah^{1

2

3}, Jackson R Del Porto^{1

2

3}, Abigail G Person^{1

2

3}, Sadie J Korzec^{1

2

3}, Kathleen E Bright^{1

2

3

5}, Genevieve Brzoza^{1

5

6}, Jessica L Heath^{1

2

3

6}, Prachi N Ghule^{1

2

3}, Jonathan A R Gordon^{1

2

3}, Andre J Van Wijnen¹, Seth E Frietze^{1

2

3

5}, Karen C Glass^{1

2

3}, Jane B Lian^{1

2

3}, Janet L Stein^{1

2

3}, Gary S Stein^{7

8

9}

Affiliations

¹ Department of Biochemistry, University of Vermont, Burlington, VT, USA.
² University of Vermont Cancer Center, University of Vermont, Burlington, VT, USA.
³ University of Vermont Larner College of Medicine, University of Vermont, Burlington, VT, USA.
⁴ Department of Pharmacology, University of Vermont, Burlington, VT, USA.
⁵ College of Nursing and Health Sciences, University of Vermont, Burlington, VT, USA.
⁶ Department of Pediatrics, University of Vermont, Burlington, VT, USA.
⁷ Department of Biochemistry, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.
⁸ University of Vermont Cancer Center, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.
⁹ University of Vermont Larner College of Medicine, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.

PMID: 40593206
DOI: 10.1007/978-3-031-91459-1_2

Review

Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer

Andrew J Fritz et al. Results Probl Cell Differ. 2025.

. 2025:75:25-69.

doi: 10.1007/978-3-031-91459-1_2.

Authors

Affiliations

¹ Department of Biochemistry, University of Vermont, Burlington, VT, USA.
² University of Vermont Cancer Center, University of Vermont, Burlington, VT, USA.
³ University of Vermont Larner College of Medicine, University of Vermont, Burlington, VT, USA.
⁴ Department of Pharmacology, University of Vermont, Burlington, VT, USA.
⁵ College of Nursing and Health Sciences, University of Vermont, Burlington, VT, USA.
⁶ Department of Pediatrics, University of Vermont, Burlington, VT, USA.
⁷ Department of Biochemistry, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.
⁸ University of Vermont Cancer Center, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.
⁹ University of Vermont Larner College of Medicine, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.

PMID: 40593206
DOI: 10.1007/978-3-031-91459-1_2

Abstract

Acetylation of histones epigenetically mediates transcriptional dynamics of gene activation and suppression in response to physiological regulatory signals. The acetylated states of histone proteins define the activities of gene promoter and enhancer elements by contributing to competency for regulatory protein interactions and control of chromatin organization including higher-order inter and intra-chromosomal interactions. Cell transformation and tumor progression are associated with and functionally related to histone acetylation. Targeting the regulatory machinery for histone acetylation provides treatment options for cancer-compromised gene expression with specificity and reduced off-target consequences.

Keywords: Acetylation; Epigenetic control; Higher-order chromatin organization; Post-translational histone modifications; Transcription.

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References

1. Abnizova I, Stapel C, Boekhorst RT, Lee JTH, Hemberg M (2024) Integrative analysis of transcriptomic and epigenomic data reveals distinct patterns for developmental and housekeeping gene regulation. BMC Biol 22(1):78 - PubMed - PMC - DOI
1. Ahmad B, Saeed A, Al-Amery A, Celik I, Ahmed I, Yaseen M et al (2024) Investigating potential cancer therapeutics: insight into histone deacetylases (HDACs) inhibitions. Pharmaceuticals (Basel) 17(4)
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1. Akalin A, Kormaksson M, Li S, Garrett-Bakelman FE, Figueroa ME, Melnick A et al (2012) methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol 13(10):R87 - PubMed - PMC - DOI
1. Alexander JM, Guan J, Li B, Maliskova L, Song M, Shen Y et al (2019) Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity. elife:8

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Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer

Affiliations

Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer

Authors

Affiliations

Abstract

References

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Medical