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Meta-Analysis
. 2025 Jul 1;15(1):21150.
doi: 10.1038/s41598-025-07327-5.

Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis

Jingxian Yang  1   2 , Yongjie Chen #  2 , Jun Wan #  1 , Feina Li  2 , Xinyu Yang  1 , Binger Shen  2 , Na Li  1 , Jiajia Didi  3 , Lijiao Zhou  2 , Yu Zhang  4   5
Affiliations
Meta-Analysis

Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis

Jingxian Yang et al. Sci Rep. .

Abstract

Stroke poses a significant mortality threat and frequently results in survivors experiencing varying degrees of residual disability. The objective of this meta-analysis was to elucidate the association between C-reactive protein-to-albumin ratio (CAR) and prognosis in patients with stroke. We searched the databases of PubMed, Embase, the Cochrane Library, and CNKI for relevant studies up to 26th January 2024. The quality of the included studies was evaluated using the Newcastle Ottawa Quality Assessment Scale (NOS). Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association between CAR and poor functional outcomes and mortality. A total of nine studies with 2954 patients were included. The pooled results demonstrated that elevated CAR was associated with poor functional outcomes in patients with stroke (OR: 2.24; 95% CI: 1.81-2.78; P < 0.00001). Similarly, elevated CAR was associated with mortality in patients with stroke (OR: 2.11; 95% CI: 1.51-2.94; P < 0.0001). CAR has prognostic value for poor functional outcomes and mortality in patients with stroke.

Keywords: Albumin; C-reactive protein; Meta-analysis; Mortality; Stroke.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Ethics approval was not obtained because this study did not involve human or animal subjects.

Figures

Fig. 1
Fig. 1
Search strategy and final included and excluded studies.
Fig. 2
Fig. 2
Forest plots for the association between CAR and poor functional outcomes.
Fig. 3
Fig. 3
Forest plots for the association between CAR and mortality.
See this image and copyright information in PMC

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