Emma Searle reports consulting fees from Sanofi, BMS, Johnson & Johnson, Syndax, Cellcentric, Sumitomo, Beigene & Pfizer; meeting and/or travel support from Johnson & Johnson, Abbvie, Beigene, and Menarini Stemline; payment or honoraria from Astellas, Jazz Pharma, Johnson & Johnson, Abbvie & Pfizer; participation on a data safety monitoring board or advisory board for Dark Blue Therapeutics, Sanofi, BMS, Johnson &Johnson, Syndax, Pfizer and Sumitomo; and leadership or fiduciary role (unpaid) with British Society of Haematology Research and Grants (Committee Chair) and ECMC Haematology Network Group (Deputy Chair). Thomas Cluzeau reports consulting fees from Abbvie, Jazz Pharma, Novartis, Agios, Servier, BluePrint and BMS; payment or honoraria from Novartis, Astellas, BMS, Jazz Pharma, Servier, and Incyte; meeting and/or travel support from Pfizer, BMS, Novartis, Abbvie, Servier, Gilead; and participation on a data safety monitoring board or advisory board for BMS, Novartis and KEROS. Jenny O'Nions reports payment or honoraria from Jazz and Astellas; meeting and/or travel support from Janssen, Abbvie, Servier and Jazz; and participation on a data safety monitoring board or advisory board for Abbvie. Christian Recher reports grants or contracts from Abbvie, Astellas, BMS, Jazz Pharma and Iqvia; payment or honoraria from Abbvie, Astellas, BMS, Jazz Pharma, Novartis and Servier; meeting and/or travel support from Abbvie, Astellas, BMS, Jazz Pharma, Novartis and Servier; and participation on a data safety monitoring board or advisory board for Abbvie, Astellas, BMS, Jazz Pharma, Novartis, Servier and Takeda. Emmanuel Gyan reports grants or contracts from Novartis; consulting fees from Janssen, Sanofi, Abbvie and Incyte; payment or honoraria from Gilead and Roche; meeting and/or travel support from Roche; and receipt of equipment, materials, drugs, medical writing, gifts or other services from BMS and Sandoz. Daniel Morillo reports payment or honoraria from Abbvie and GSK; and meeting and/or travel support from Roche, Janssen and Kite. Jordi Esteve reports grants or contracts (to CETLAM cooperative group) from Jazz and Pfizer; payment or honoraria from Abbvie and Jazz; and meeting and/or travel support from Abbvie. Austin Kulasekararaj reports consulting fees from Novartis, SOBI, Alexion/AstraZeneca, Novartis and Roche; payment or honoraria from Celgene/BMS, Novartis, SOBI, Alexion/AstraZeneca, Roche, Samsung, and Amgen; meeting and/or travel support from SOBI and Alexion/AstraZeneca; and participation on a data safety monitoring board or advisory board for Agious, Roche and Biocryst. Emmanuel Raffoux reports consulting fees from Servier and BMS; and payment or honoraria from Servier, BMS and Astellas. Harriet Walter reports research funding paid by Janssen to institutions; medical education grant from Pfizer and research funding from Isogenica and Gilead; payment or honoraria from Abbvie; and participation on a data safety monitoring board or advisory board for Beigene, Eli Lilly and Genmab. Arnaud Pigneux has nothing to report. David Valcárcel reports consulting fees from Amgen, BMS/Celgene, Kite/Gilead, Novartis, SOBI, Astellas, Jazz, MSD and Sanofi; payment or honoraria from Amgen, BMS/Celgene, Grifols, Jazz, MSD, Pfizer, SOBI, Astellas, GEBRO, Janssen, Kite/Gilead, Novartis, Sanofi and Agios; meeting and/or travel support from BMS/Celgene, Jazz, SOBI, Novartis and Sanofi; and participation on a data safety monitoring board or advisory board for Novartis, SOBI, BMS/Celgene, Jazz, Servier, Amgen and Grifols. Nikki Daskalakis, Jacqueline Bussolari, E. Christine Pietsch, Scott Kuduk, Tammy Bush, Xiaochun Zhang, Ulrike Philippar, Adetokunbo Oluwasanjo (at time of study conduct), Kathryn Bradford, Jonathan Miller, Charlotte Van Bogaert, Martin Curtis, Shih‐Yu Chang, Christina Guttke, Stan Gaj, Rachel Pearson, Joseph Murphy and Wim van Dijck are employees of Janssen and may hold company stock in the company. E. Christine Pietsch and Christina Guttke also report patents planned, issued or pending, and Ulrike Philippar also reports a leadership or fiduciary role with J&J Belgium (Board of Directors). Ana Alfonso Piérola reports grants or contracts from AstraZeneca; consulting fees from Jazz Pharmaceuticals and Astellas; payment or honoraria from Novartis, BMS, Jazz Pharmaceuticals, Astellas and Abbvie; and meeting and/or travel support from Kite, BMS and Novartis.