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. 2025 May;18(5):440-448.
doi: 10.25122/jml-2025-0082.

Chemical burns: pathophysiology and therapeutic protocols-do cervico-facial injuries pose specific challenges?

Rares-Adrian Giurgiu  1 , Catalina-Stefania Dumitru  1 , Andreea Grosu-Bularda  1 , Eliza-Maria Bordeanu-Diaconescu  2 , Adrian Frunza  1   2 , Sabina Grama  2 , Florin-Vlad Hodea  1 , Tiberiu-Paul Neagu  1   2 , Ioan Lascar  1 , Cristian-Sorin Hariga  1
Affiliations

Chemical burns: pathophysiology and therapeutic protocols-do cervico-facial injuries pose specific challenges?

Rares-Adrian Giurgiu et al. J Med Life. 2025 May.

Abstract

Chemical burns, though relatively rare, present significant diagnostic and therapeutic challenges due to their complex pathophysiology and the need for specialized care. A retrospective study was conducted, examining the characteristics, treatment, and outcomes of 33 patients with chemical burns admitted to our burn center for 8 years, representing 4.39% of all burn cases. Among them, 15 patients (45.45%) had chemical burns on the face and neck. The majority of these patients were men, with a relatively younger average age, and a significant proportion had work-related accidents. The burned surface area was variable, with many patients sustaining small total body surface area (TBSA), although some presented with extensive involvement. The prevalence of superficial partial-thickness burns was higher, but deep partial-thickness and full-thickness burns were also common. A large proportion of patients had favorable Abbreviated Burn Severity Index (ABSI) scores, indicating a high probability of survival. However, ocular involvement was a major complication. The study emphasizes the importance of timely intervention, including appropriate wound management strategies, specialized dressings, and skin substitutes. The findings also stress the need for a multidisciplinary approach, close monitoring, and adherence to safety protocols to optimize outcomes and minimize long-term complications in patients with chemical burns, particularly those of the face and neck region.

Keywords: burns; chemical agents; dressings; surgical treatment; therapeutic algorithm.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Etiological agents of chemical burns
Figure 2
Figure 2
Etiologic agents of face and neck chemical burns
Figure 3
Figure 3
Advanced wound dressings in burn management. A, Aquacel Ag Burn Hydrofiber, a non-woven hydroentangled dressing comprised of hydrofiber (sodium carboxymethylcellulose) with nylon thread; B, Integra following a deep burn excision, the dermal matrix with the overlying silicone epidermal layer was applied; C, Epicite Hydro, a hydro-active dressing that creates a moist and supportive environment for wound healing used in a patient with chemical burns on the face.
Figure 4
Figure 4
Sodium hydroxide (caustic soda) chemical burns and reconstruction. A, Acute full-thickness facial burns, including periocular involvement; B, upper limb; C, lower limb; D, Skin grafts in the upper limb; E, Skin grafts in the lower limb.
Figure 5
Figure 5
Reconstruction of facial chemical burns with split-thickness skin grafts. A, B Full-sheet split-thickness skin grafts used for definitive coverage after the excision of chemical burns on the face; C, Postoperative aspect on day 30 after skin grafting.
Figure 6
Figure 6
Therapeutic algorithm of chemical burns: particularities of cervico-facial burns
See this image and copyright information in PMC

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References

    1. Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020 Feb 13;6(1):11. doi: 10.1038/s41572-020-0145-5. - DOI - PMC - PubMed
    1. Yin B, He Y, Zhang Z, Cheng X, Bao W, Li S, et al. Global burden of burns and its association with socio-economic development status, 1990-2019. Burns. 2024 Mar;50(2):321–374. doi: 10.1016/j.burns.2023.02.007. - DOI - PubMed
    1. Badoiu SC, Enescu DM, Tatar R, Miricescu D, Stanescu-Spinu II, Greabu M, et al. Adipokines-A Cohort Prospective Study in Children with Severe Burns. Int J Mol Sci. 2024 Jul 11;25(14):7630. doi: 10.3390/ijms25147630. - DOI - PMC - PubMed
    1. Parry I, Bell J. Associations between burn care services and impairment at discharge after burn injury: Analysis of the Global Burn Registry. Burns. 2024 May;50(4):813–822. doi: 10.1016/j.burns.2024.03.002. - DOI - PubMed
    1. Bordeanu-Diaconescu EM, Grosu-Bularda A, Frunza A, Grama S, Andrei MC, Neagu TP, et al. Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries. Diagnostics (Basel) 2024 Mar 9;14(6):582. doi: 10.3390/diagnostics14060582. - DOI - PMC - PubMed

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