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. 2025 Jun 14:40:100542.
doi: 10.1016/j.jctube.2025.100542. eCollection 2025 Aug.

Effect of home-based pulmonary rehabilitation on ventilation dynamics and small airway dysfunction in people with post-tuberculosis lung disease

Iasmim Maria Pereira Pinto Fonseca  1 , Samantha Gomes de Alegria  1 , Jéssica Gabriela Messias Oliveira  1 , Thaís Souza Rodrigues  2 , Carolina Alves Osório da Silva Chagas  2 , Alícia Sales Carneiro  3 , Walter Costa  3 , Ana Paula Santos  3 , Thiago Thomaz Mafort  1   3 , Agnaldo José Lopes  1   3   4
Affiliations

Effect of home-based pulmonary rehabilitation on ventilation dynamics and small airway dysfunction in people with post-tuberculosis lung disease

Iasmim Maria Pereira Pinto Fonseca et al. J Clin Tuberc Other Mycobact Dis. .

Abstract

Background: As the world moves toward eliminating tuberculosis (TB), there is a large population of TB survivors who still face a significant burden of TB complications. However, basic pulmonary rehabilitation program (PRP) packages for this population are currently lacking. This study aimed to evaluate the effect of home-based PRP (HBPRP) on lung mechanics, exercise capacity, and quality of life (QoL) in people with PTLD (pwPTLD).

Methods: This is a quasi-experimental study in pwPTLD who underwent HBPRP for 3 months. Before and after HBPRP, the following assessments were performed: QoL using the St George's Respiratory Questionnaire (SGRQ), general fatigue using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), handgrip strength (HGS), pulmonary function, and functional exercise capacity using the Glittre-ADL test (TGlittre) coupled with measurement of dynamic ventilation.

Results: When comparing pre- and post-HBPRP values, there was a significant increase in TGlittre time [208 (194-249) vs. 184 (153-211) seconds, P = 0.004] and breathing reserve [56 (34-71) vs. 58 (39-73) %, P = 0.032], and a reduction in end-of-test inspiratory capacity [1.4 (0.9-2.3) vs. 1.6 (1.1-2.6) L, P = 0.030]. Although no increase in spirometric parameters was observed, there was an improvement in small airway dysfunction (SAD) as measured by respiratory oscillometry. Improvements were observed in the Activity and Impacts domains of the SGRQ. However, no significant changes were noted in FACIT-F or HGS after HBPRP.

Conclusions: In pwPTLD, HBPRP improves exercise tolerance, QoL, and SAD, with no effect on general fatigue and HGS. Therefore, TB programs should ensure the availability of PRP for pwPTLD, including HBPRP.

Keywords: Muscle strength; Pulmonary function; Quality of life; Rehabilitation.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Comparison of area under the reactance curve (AX) between pre- and post-home-based pulmonary rehabilitation program assessments (P = 0.039).
Fig. 2
Fig. 2
Comparison of Glittre-ADL test time between pre- and post-home-based pulmonary rehabilitation program assessments (P = 0.004).
See this image and copyright information in PMC

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References

    1. Yarbrough C., Miller M., Zulu M., Sharp D., Andom A.F., Ndayizigiye M., et al. Post-tuberculosis lung disease: addressing the policy gap. PLOS Glob Public Health. 2024;4(9) doi: 10.1371/journal.pgph.0003560. - DOI - PMC - PubMed
    1. Mpagama S.G., Msaji K.S., Kaswaga O., Zurba L.J., Mbelele M.P., Allwood B.W., et al. The burden and determinants of post-TB lung disease. Int. J. Tuberc. Lung Dis. 2021;25(10):846–853. doi: 10.5588/ijtld.21.0278. - DOI - PMC - PubMed
    1. Dodd P.J., Yuen C.M., Jayasooriya S.M., van der Zalm M.M., Seddon J.A. Quantifying the global number of tuberculosis survivors: a modelling study. Lancet Infect. Dis. 2021;21(7):984–992. doi: 10.1016/S1473-3099(20)30919-1. - DOI - PubMed
    1. Byrne A., Al-Hindawi Y., Plit M., Yeung L., Rigava S., King M., et al. The prevalence and pattern of post tuberculosis lung disease including pulmonary hypertension from an Australian TB service; a single-centre, retrospective cohort study. BMC Pulm. Med. 2025;25(1):84. doi: 10.1186/s12890-025-03549-5. - DOI - PMC - PubMed
    1. Kempker RR, Salindri AD, Avaliani T, Kornfeld H, Auld SC, Jakobia N, et al. High rates of post-tuberculosis lung disease among persons successfully treated for drug-susceptible and resistant tuberculosis. Thorax 2025. https://doi.org/10.1136/thorax-2024-222350. Online ahead of print. - PubMed

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