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. 2025 Mar 31;21(3):290-296.
doi: 10.6026/973206300210290. eCollection 2025.

Molecular docking analysis of bioactive molecules from herbs with snake venom phospholipase A2

Karthik Nagarajan S  1 , Siva Annamalai  2 , Bharath Christian C B S  1 , Rajamaheswari K  1 , Lavanya A  1 , Arunachalam K  3
Affiliations

Molecular docking analysis of bioactive molecules from herbs with snake venom phospholipase A2

Karthik Nagarajan S et al. Bioinformation. .

Abstract

Snake venom, particularly phospholipase A2 (PLA2), exerts profound pathological effects, necessitating the development of potent therapeutic interventions. Therefore, it is of interest to the inhibitory potential of bioactive phytoconstituents from select medicinal herbs with PLA2. Analysis showed that Gymnemic acid, Aristolochic acid, Lupeol and Tocopherol are the best PLA2 inhibitors with strong binding and molecular interactions for further consideration.

Keywords: Molecular docking; network pharmacology; phospholipase A2.

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Conflict of interest statement

None

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