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. 2025 Jul 2.
doi: 10.14309/ajg.0000000000003629. Online ahead of print.

Adding Clip Before Endoscopic Cyanoacrylate Injection Decreases Ectopic Embolisms in Gastric Varices: A Randomized Controlled Trial

Guangchuan Wang  1   2   3 , Lijun Peng  4   5 , Ping Li  6 , Haijun Mou  7 , Xiaopei Li  8 , Qun Li  9 , Xingsi Qi  10 , Kemei Lu  11 , Huijing Yao  12 , Wei Wang  13 , Lianhui Zhao  2 , Yifu Xia  1   2 , Mingyan Zhang  1   2 , Junyuan Zhu  1 , Jiali Ma  14 , Junshan Li  8 , Congxiang Li  15 , Xiaofeng Liu  9 , Biguang Tuo  7 , Xiubin Sun  3 , Juan Carlos García-Pagán  16 , Chunqing Zhang  1   2
Affiliations

Adding Clip Before Endoscopic Cyanoacrylate Injection Decreases Ectopic Embolisms in Gastric Varices: A Randomized Controlled Trial

Guangchuan Wang et al. Am J Gastroenterol. .

Abstract

Introduction: Ectopic embolism caused by cyanoacrylate migration is a severe complication. We aimed to test the hypothesis that prior clipping can reduce ectopic embolism secondary to endoscopic cyanoacrylate injection (ECI) in gastric varices with a gastrorenal shunt.

Methods: In this multicenter, open-label, parallel, randomized controlled trial, patients with fundal gastric varices and gastrorenal shunts from 10 tertiary hospitals were randomly assigned to clip-assisted ECI (Clip-ECI, n = 35) and conventional ECI groups (Con-ECI, n = 35). The primary outcome was the occurrence of ectopic embolism. Computed tomography was performed within 48 hours of the initial injection to screen for cyanoacrylate (marked with lipiodol) migration.

Results: The technical success rate was 100% in both groups. The Clip-ECI group had a significantly lower incidence of cyanoacrylate embolism than the Con-ECI group (11.4% vs 42.9%, P = 0.003). Symptomatic pulmonary embolism occurred in 4 patients in the Con-ECI group, of which 1 patient died. By contrast, no symptomatic embolism event was observed in the Clip-ECI group (11.4% vs 0%, P = 0.114). No clip-related bleeding was reported. No significant differences were observed in the total rebleeding rate (14.3% vs 14.3%) and survival rate (97.1% vs 93.9%) between the Clip-ECI and Con-ECI groups during a median follow-up of 10.1 (interquartile range 7.7-12.9) and 9.9 (interquartile range 6.3-12.6) months, respectively.

Discussion: Clipping before ECI reduces the risk of ectopic embolism in patients with fundal varices with a portal-systemic shunt, without compromising safety or efficacy.

Keywords: clip; ectopic embolism; endoscopic cyanoacrylate injection; gastric varices.

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