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Review
. 2025 Aug;42(3-4):125-135.
doi: 10.1007/s10719-025-10188-9. Epub 2025 Jul 2.

Progress in research on DDOST dysregulation in related diseases

Haoan Sun  1 , Chunbao Xie  2
Affiliations
Review

Progress in research on DDOST dysregulation in related diseases

Haoan Sun et al. Glycoconj J. 2025 Aug.

Abstract

DDOST is an important subunit of N-glycosylated oligosaccharyltransferase and is closely related to protein N-glycosylation. Some studies have reported that abnormal expression of DDOST is associated with congenital disorders of glycosylation, solid tumours and other diseases. To better understand the progress of research on DDOST in diseases, we herein provide a comprehensive review of the basic functions of DDOST, interactions molecules, DDOST-congenital disorders of glycosylation (DDOST-CDG) and solid tumours. Our review findings will lay a foundation for researchers to better understand the functions of DDOST and to investigate its specific mechanisms of action.

Keywords: DDOST; Cancer; Congenital disorders of glycosylation; N-glycosylation.

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Conflict of interest statement

Declarations. Ethical approval: This study does not involve human participants and ethical approval was not required. Informed consent: Not applicable. Competing interests: The authors declare no competing interests.

References

    1. Schjoldager, K.T., Narimatsu, Y., Joshi, H.J., Clausen, H.: Global view of human protein glycosylation pathways and functions. Nat. Rev. Mol. Cell. Biol. 21(12), 729–749 (2020). https://doi.org/10.1038/s41580-020-00294-x - DOI - PubMed
    1. Oliveira-Ferrer, L., Legler, K., Milde-Langosch, K.: Role of protein glycosylation in Cancer metastasis. Semin Cancer Biol. 44, 141–152 (2017). https://doi.org/10.1016/j.semcancer.2017.03.002 - DOI - PubMed
    1. Shapanis, A., Lai, C., Smith, S., Coltart, G., Sommerlad, M., Schofield, J., Parkinson, E., Skipp, P., Healy, E.: Identification of proteins associated with development of metastasis from cutaneous squamous cell carcinomas (cSCCs) via proteomic analysis of primary cSCCs. Br. J. Dermatol. 184(4), 709–721 (2021). https://doi.org/10.1111/bjd.19485 - DOI - PubMed
    1. Zhu, C., Xiao, H., Jiang, X., Tong, R., Guan, J.: Prognostic biomarker DDOST and its correlation with immune infiltrates in hepatocellular carcinoma. Front. Genet. 12, 819520 (2022). https://doi.org/10.3389/fgene.2021.819520 - DOI - PubMed - PMC
    1. Ramírez, A.S., Kowal, J., Locher, K.P.: Cryo–Electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Science. 366(6471), 1372–1375 (2019). https://doi.org/10.1126/science.aaz3505 - DOI - PubMed

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