Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 2;20(7):e0327236.
doi: 10.1371/journal.pone.0327236. eCollection 2025.

Pathophysiological mechanisms of Postural Orthostatic Tachycardia Syndrome analyzed by means of hemodynamics

Liuchuang Wei  1 , Heming Cheng  1 , Suihai Chen  1 , Jifeng Dai  1 , Gen Li  1 , Dongfang Ding  1 , Xue Zhang  1 , Ke Zhang  2 , Jianyun Li  1 , Jie Hou  1
Affiliations

Pathophysiological mechanisms of Postural Orthostatic Tachycardia Syndrome analyzed by means of hemodynamics

Liuchuang Wei et al. PLoS One. .

Abstract

Postural Orthostatic Tachycardia Syndrome is characterized by an excessive increase in heart rate during postural changes without significant blood pressure alterations, often accompanied by symptoms such as dizziness, fatigue, and palpitations. While prior studies have explored potential mechanisms, the precise etiology and pathological basis of Postural Orthostatic Tachycardia Syndrome remain unclear, leading to treatments focused on symptom management rather than addressing root causes. This study employs a hemodynamic fluid-structure interaction model (using existing clinical data) to investigate the roles of hypovolemia, vascular dysfunction, and autonomic nervous system dysregulation in Postural Orthostatic Tachycardia Syndrome pathogenesis. Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction-marked by a 50-100% increase in arterial stiffness-further diminishes cardiac output and cerebral perfusion. These conditions trigger compensatory tachycardia through autonomic feedback mechanisms. Our findings demonstrate that an insufficient cerebral blood supply, driven by hypovolemia and impaired vascular compliance, combined with autonomic dysregulation, underlies the hallmark tachycardia in Postural Orthostatic Tachycardia Syndrome. This mechanistic insight provides a foundation for targeted therapeutic strategies, emphasizing the need to address blood volume management, vascular elasticity, and autonomic balance to improve clinical outcomes.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic diagram of aortic wall elasticity.
Notes: a) Ventricular systole, b) Ventricular diastole.
Fig 2
Fig 2. Supine and upright HR and BP schematic diagram.
Notes: Supine and upright HR (orange) and BP (blue) profiles of healthy controls (left panel) and POTS patients (right panel) demonstrating an exaggerated HR increase (>30 bpm) and relatively stable BP.
Fig 3
Fig 3. Healthy control group HR and CBF changes.
Fig 4
Fig 4. Healthy control group HR and CBF, hypovolemia-induced POTS HR and CBF changes.
Fig 5
Fig 5. Healthy control group HR and CBF, vascular dysfunction-induced POTS HR and CBF changes.
See this image and copyright information in PMC

References

    1. Sheldon RS, Grubb BP 2nd, Olshansky B, Shen W-K, Calkins H, Brignole M, et al. 2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015;12(6):e41–63. doi: 10.1016/j.hrthm.2015.03.029 - DOI - PMC - PubMed
    1. Safavi-Naeini P, Razavi M. Postural orthostatic tachycardia syndrome. Tex Heart Inst J. 2020;47(1):57–9. doi: 10.14503/THIJ-19-7060 - DOI - PMC - PubMed
    1. Raj SR. Postural tachycardia syndrome (POTS). Circulation. 2013;127(23):2336–42. doi: 10.1161/CIRCULATIONAHA.112.144501 - DOI - PMC - PubMed
    1. Low PA, Sandroni P. Postural tachycardia syndrome (POTS) – science direct. Primer ANS. 2012:517–9. doi: 10.1016/b978-0-12-386525-0.00106-2 - DOI
    1. Goldstein DS. The possible association between COVID-19 and postural tachycardia syndrome. Heart Rhythm. 2021;18(4):508–9. doi: 10.1016/j.hrthm.2020.12.007 - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources