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. 2025 Sep;27(9):5362-5365.
doi: 10.1111/dom.16563. Epub 2025 Jul 2.

Reduced prandial insulin secretion contributes to prandial hyperglycaemia in non-diabetic individuals with spinal cord injury

Michelle Trbovich  1   2 , Sven Hoekstra  3   4 , Amalia Gastaldelli  5 , Marzieh Salehi  2   6
Affiliations

Reduced prandial insulin secretion contributes to prandial hyperglycaemia in non-diabetic individuals with spinal cord injury

Michelle Trbovich et al. Diabetes Obes Metab. 2025 Sep.
No abstract available

Keywords: beta cell function; clinical physiology; glycaemic control; insulin secretion.

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Figures

FIGURE 1
FIGURE 1
Glucose concentration (A), insulin secretion rate (B), insulin secretion rate over glucose concentration (C), β‐cell glucose sensitivity, calculated as the upward slope of ISR over glucose concentration (D), and metabolic insulin clearance (E) in persons with spinal cord injury (SCI; black circles, solid line) and able‐bodied controls (AB; white circles, dashed line) during a mixed meal tolerance test. ISR, insulin secretion rate. *p < 0.05 between SCI and AB, with the specific p‐values: 0.039 (1A); 0.046 (1C); 0.025 (1D). Data are presented as mean ± SEM and the differences between groups are compared using paired t tests.
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References

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