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Review
. 2025 Jul 2.
doi: 10.1111/odi.70018. Online ahead of print.

Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review

Anna Simonelli  1   2 , Filippo Citterio  3 , Fabio Falcone  4   5 , Francesco D'Aiuto  6 , Nicola Marco Sforza  7 , Salvatore Corrao  4   5 , Giorgio Sesti  8 , Leonardo Trombelli  1   2
Affiliations
Review

Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review

Anna Simonelli et al. Oral Dis. .

Abstract

Aim: To evaluate the effects of periodontal treatment on metabolic syndrome (MS) parameters and systemic inflammatory biomarker levels in patients affected by both MS and periodontitis.

Methods: A systematic search was conducted to identify randomized controlled trials (RCTs) with a follow-up ≥ 1 month comparing a more intense periodontal treatment (test intervention) to either a less intense or no periodontal treatment (control intervention). MS parameters such as triglycerides (TG), high-density lipoprotein cholesterol (HDL), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), and systemic inflammatory biomarkers (i.e., C-reactive protein, CRP) were analyzed. Random-effects meta-regression analyses were conducted at 3- and 6-month follow-ups.

Results: Four RCTs were included. Test intervention resulted in a statistically significant greater SBP reduction at 3 (WMD 1.48) and 6 (WMD 1.88) months compared to control group. A statistically significant difference between groups was observed for FBG at 6 months after treatment, favoring test intervention (WMD 0.61). No differences were observed for the other MS parameters and for CRP at both 3- and 6-month follow-up.

Conclusions: Periodontal treatment seems to have beneficial effects on SBP and FBG in patients with MS and periodontitis at 3-6-month follow-ups.

Trial registration: This systematic review was registered under the protocol registration number CRD42024499854/PROSPERO.

Keywords: metabolic syndrome; non‐surgical periodontal therapy; periodontitis; systematic review; systemic inflammation.

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References

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