Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 3.
doi: 10.1111/aor.15055. Online ahead of print.

Dobutamine Use in Patients With Extracorporeal Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest: A Secondary Analysis of the SAVE-J II Study

Tasuku Hada  1 , Toru Hifumi  1 , Hiromu Okano  2 , Kasumi Shirasaki  1 , Shutaro Isokawa  1 , Akihiko Inoue  3 , Tetsuya Sakamoto  4 , Yasuhiro Kuroda  5 , Norio Otani  1 ; SAVE‐J II Study Group
Collaborators, Affiliations

Dobutamine Use in Patients With Extracorporeal Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest: A Secondary Analysis of the SAVE-J II Study

Tasuku Hada et al. Artif Organs. .

Abstract

Background: The effects of dobutamine on outcomes in patients experiencing out-of-hospital cardiac arrest (OHCA), treated with extracorporeal cardiopulmonary resuscitation (ECPR), remain unclear. In this study, we aimed to evaluate the association between dobutamine use within 24 h and clinical outcomes in patients with OHCA who underwent ECPR.

Methods: A post hoc analysis was conducted on the registry data from the SAVE-J II study (2013-2018). To address potential confounding variables related to dobutamine administration, 1:3 propensity score matching was employed using the patients' baseline characteristics. Following the matching, the dobutamine and non-dobutamine groups were compared, focusing on in-hospital mortality and neurological outcomes assessed using the cerebral performance category (CPC) scale.

Results: Of the 2157 registered cases, 581 cases of cardiogenic OHCA treated with targeted temperature management were included in this analysis. Eighty-eight patients who received dobutamine were compared with 264 who did not after propensity score matching. The in-hospital mortality rate was 60.2% in the dobutamine group, compared with 58.3% in the non-dobutamine group (p = 0.80). The proportion of patients with a CPC score of 3-5 at hospital discharge was 79.5% in the dobutamine group, compared with 78.0% in the non-dobutamine group (p = 0.88). A Kaplan-Meier analysis demonstrated no significant differences in survival rates between the two groups (42.1 vs. 43.6%, log-rank p = 0.79).

Conclusion: In patients with OHCA who underwent ECPR, dobutamine administration within 24 h was not significantly associated with in-hospital mortality and neurological outcomes.

Keywords: dobutamine; extracorporeal cardiopulmonary resuscitation; in‐hospital mortality; neurological outcomes; out‐of‐hospital cardiac arrest.

PubMed Disclaimer

References

    1. D. Miraglia, L. A. Miguel, and W. Alonso, “Extracorporeal Cardiopulmonary Resuscitation for In‐ and Out‐Of‐Hospital Cardiac Arrest: Systematic Review and Meta‐Analysis of Propensity Score‐Matched Cohort Studies,” Journal of the American College of Emergency Physicians Open 1, no. 4 (2020): 342–361, https://doi.org/10.1002/emp2.12091.
    1. T. E. Klee and K. B. Kern, “A Review of ECMO for Cardiac Arrest,” Resuscitation Plus 5 (2021): 100083, https://doi.org/10.1016/j.resplu.2021.100083.
    1. T. Sakamoto, N. Morimura, K. Nagao, et al., “Extracorporeal Cardiopulmonary Resuscitation Versus Conventional Cardiopulmonary Resuscitation in Adults With Out‐Of‐Hospital Cardiac Arrest: A Prospective Observational Study,” Resuscitation 85, no. 6 (2014): 762–768, https://doi.org/10.1016/j.resuscitation.2014.01.031.
    1. A. Zia and K. B. Kern, “Management of Postcardiac Arrest Myocardial Dysfunction,” Current Opinion in Critical Care 17 (2011): 241–246, https://doi.org/10.1097/MCC.0b013e3283447759.
    1. A. Chalkias and T. Xanthos, “Pathophysiology and Pathogenesis of Post‐Resuscitation Myocardial Stunning,” Heart Failure Reviews 17, no. 1 (2012): 117–128, https://doi.org/10.1007/s10741‐011‐9255‐1.

LinkOut - more resources