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. 2025 Jul 3;20(7):e0327518.
doi: 10.1371/journal.pone.0327518. eCollection 2025.

Expression of Concern: Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells

PLOS One Editors

Expression of Concern: Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells

PLOS One Editors. PLoS One. .
No abstract available

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Figures

Fig 6
Fig 6. CAIX expression affects migration and invasion of breast cancer cells.
Cell migration and invasion were determined using trans-well chambers. Panel A. UFH-001 cells (empty vector and CRISPR-CAIX knockdown cells from Fig 5) were plated in the upper transwell chambers and allowed to migrate or invade across the membrane for 24 h (upper images) or 48 h (lower images), respectively. Tabulation of results is shown to the right (p < 0.05). Panel B. T47D cells (empty vector or CAXII knockdown cells from Fig 4) were plated in the upper transwell chambers and allowed to migrate or invade across the membrane for 24 h (upper images) or 48 h (lower images), respectively. Tabulation of results is shown to the right.
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Expression of concern for

References

    1. Chen Z, Ai L, Mboge MY, Tu C, McKenna R, Brown KD, et al. Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells. PLoS One. 2018;13(7):e0199476. doi: 10.1371/journal.pone.0199476 - DOI - PMC - PubMed
    1. Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, et al. Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition. PLoS One. 2018;13(11):e0207417. doi: 10.1371/journal.pone.0207417 - DOI - PMC - PubMed
    1. Chen Z, Ai L, Mboge MY, McKenna R, Frost CJ, Heldermon CD, et al. UFH-001 cells: A novel triple negative, CAIX-positive, human breast cancer model system. Cancer Biol Ther. 2018;19(7):598–608. doi: 10.1080/15384047.2018.1449612 - DOI - PMC - PubMed
    1. https://kmplot.com/analysis

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