Expanding the reach of molecular glue degraders

Marcus D Hartmann^{1

2}

Affiliations

¹ Department of Protein Evolution, Max Planck Institute for Biology, Tübingen, Germany.
² Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.

Comment

Marcus D Hartmann. Science. 2025.

. 2025 Jul 3;389(6755):32-33.

doi: 10.1126/science.ady4446. Epub 2025 Jul 3.

Marcus D Hartmann^{1

2}

¹ Department of Protein Evolution, Max Planck Institute for Biology, Tübingen, Germany.
² Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.

Abstract

An epitope-centric screening approach widens the neosubstrate landscape for targeted protein degradation.

Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition.
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