A tighter grip on gene expression

Filip Nemčko¹, Alexander Stark^{1

2}

Affiliations

¹ Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
² Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria.

Comment

Filip Nemčko et al. Science. 2025.

. 2025 Jul 3;389(6755):31-32.

doi: 10.1126/science.adz2519. Epub 2025 Jul 3.

Filip Nemčko¹, Alexander Stark^{1

2}

¹ Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
² Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria.

Abstract

A previously unknown cofactor function stabilizes transcription factor binding across the genome.

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression.
Bianchi D, Borza R, De Zan E, Huelsz-Prince G, Gregoricchio S, Dekker M, Fish A, Mazouzi A, Kroese LJ, Linder S, Hernandez-Quiles M, Vermeulen M, Celie PHN, Krimpenfort P, Song JY, Zwart W, Wessels L, Nijman SMB, Perrakis A, Brummelkamp TR. Bianchi D, et al. Science. 2025 Jul 3;389(6755):eadv2861. doi: 10.1126/science.adv2861. Epub 2025 Jul 3. Science. 2025. PMID: 40608935