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. 2025 Jul 3;37(1):205.
doi: 10.1007/s40520-025-03116-2.

Association between daily sitting time and accelerated aging in women: double mediation effects of systemic immune-inflammation index and creatinine

Jiali Xiong  1 , Lizhong Yin  1 , Xia Li  2 , Huiyan Wang  3 , Bin Yu  4
Affiliations

Association between daily sitting time and accelerated aging in women: double mediation effects of systemic immune-inflammation index and creatinine

Jiali Xiong et al. Aging Clin Exp Res. .

Abstract

Objective: To clarify the association between daily sitting time and accelerated aging in women, and explored that systemic immune-inflammation index and creatinine together play an important mediating effect throughout the process.

Methods: A total of 5578 women during 2007 to 2010 from the National Health and Nutrition Examination Survey was utilized in this study. Phenotypic age calculation, logistic regression analysis, restricted cubic spline model, and subgroup analysis were employed to investigate the association between daily sitting time and accelerated aging as well as its influencing factors.

Results: The threshold effect analysis identified 7 h as the inflection point. For every hour of sitting above the inflection point, the risk of accelerated aging will increase by 12.00%. Logistic regression analysis indicated that, compared to women who spent less than 4 h being sedentary during the day, the risk of accelerated aging increased 49.0%, 77%, 110% in the women spent 4 ~ 6 h (OR = 1.49, 95%CI 1.18,1.88, p = 0.0008), 6 ~ 8 h(OR = 1.77, 95%CI 1.36, 2.28, p < 0.001) and at least 8 h(OR = 2.10, 95%CI 1.70, 2.61, p < 0.001) respectively. Restricted cubic spline models validated nonlinear associations between the systemic immune-inflammation index, creatinine, and accelerated aging (p for nonlinearity < 0.001). Parallel mediation analysis found that although systemic immune-inflammation index and creatinine had significant mediating effects (p < 0.001) in the process of daily sitting time leading to accelerated aging, and they were a parallel double mediation effect.

Conclusions: Prolonged sitting time is significantly associated with accelerated aging, systemic immune-inflammation index and creatinine levels play important mediating roles in this process.

Keywords: Accelerated aging; Creatinine; Daily sitting time; Sedentary behavior; Systemic immune-inflammation index.

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Conflict of interest statement

Declarations. Ethical approval: NHANES data were collected in accordance with ethical guidelines and were approved by the NCHS Research Ethics Review Board (Protocol #2005-06). This study will be conducted within the framework of these ethical guidelines. Consent to publish: All authors approved the final manuscript and the submission to this journal. Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart for subject selection. NHANES: National Health and Nutrition Examination Survey. SII: Systemic Immune-Inflammation Index
Fig. 2
Fig. 2
Association of daily sitting time with accelerated aging among participants by curve smoothing plot
Fig. 3
Fig. 3
Double mediation effects of SII and Cre. a: Prediction plot showing association of SII with daily sitting time among participants by by restricted cubic splines. b: Prediction plot showing association of Cre with daily sitting time among participants by by restricted cubic splines. c: Double mediation effects of SII and Cre on daily sitting time and accelerated aging. RSC: restricted cubic spline
Fig. 4
Fig. 4
Forest plots of subgroups analyses of the effect of daily sitting time and accelerated aging
See this image and copyright information in PMC

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