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Review
. 2025 Jul 3;22(1):28.
doi: 10.1186/s12979-025-00522-y.

Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol

Mohamed Ahmed  1
Affiliations
Review

Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol

Mohamed Ahmed. Immun Ageing. .

Abstract

Aging is a multifactorial biological process driven by oxidative stress, chronic inflammation, genomic instability, and mitochondrial dysfunction. Recent research underscores the potential of naturally derived compounds to modulate these aging hallmarks. Curcumin, epigallocatechin gallate (EGCG), thymoquinone, and resveratrol exhibit antioxidant, anti-inflammatory, and autophagy-enhancing effects that target core pathways involved in cellular senescence and tissue degeneration. These phytochemicals regulate key molecular players such as sirtuins, AMPK, NF-κB, and mTOR, offering promise in delaying age-associated pathologies and promoting longevity. This review discusses the molecular mechanisms underlying their anti-aging actions and highlights their potential as dietary geroprotective interventions.

Keywords: Aging; And Resveratrol; Curcumin; Epigallocatechin gallate; Thymoquinone.

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Conflict of interest statement

Declarations. Ethical approval: All sources of information, including peer-reviewed literature and reputable scientific databases, have been properly cited to ensure intellectual honesty and transparency. No data has been fabricated, manipulated, or misrepresented. The review does not involve any human or animal experiments, and all findings are based on previously published research. Misleading claims, sensationalism, or unsupported conclusions have been avoided to ensure scientific integrity. Informed consent: Not applicable. Competing interests: The authors declare no competing interests.

References

    1. López-Otín C, et al. The hallmarks of aging. Cell. 2013;153(6):1194–217. - PMC - PubMed
    1. Kennedy BK, et al. Geroscience: linking aging to chronic disease. Cell. 2014;159(4):709–13. - PMC - PubMed
    1. López-Otín C, et al. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243–78. - PubMed
    1. Maldonado E, et al. Aging hallmarks and the role of oxidative stress. Antioxidants. 2023;12(3):651. - PMC - PubMed
    1. Blaakilde AL, Christensen K, Liveng A. Ageing abjection from a COVID-19 crisis perspective, in Sustainable health and the Covid-19 crisis. Routledge; 2023;80–96.

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