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. 2025 Jul 3;25(1):270.
doi: 10.1186/s12893-025-03028-y.

Clinical application of preoperative volumetric measurement for interventional precise embolization in the treatment of hypersplenism caused by liver cirrhosis

Yin-Bao Hu  1 , Lei Duan  1 , Guang-Yu Liu  1 , Xiao-Ming Wang  2
Affiliations

Clinical application of preoperative volumetric measurement for interventional precise embolization in the treatment of hypersplenism caused by liver cirrhosis

Yin-Bao Hu et al. BMC Surg. .

Abstract

Objective: Volume measurement software is not routinely utilized in clinical practice before splenic artery embolization. To explore the function of such software measurement in this context, we conducted a retrospective study.

Methods: We divided patients into two groups: 38 patients in Group A underwent three-dimensional reconstruction using Revolution CT, and 37 patients in Group B underwent imaging with normal CT technology. We compared the changes in liver function test results and haematological parameters between these two groups.

Results: A total of 75 patients who underwent splenic artery embolization from January 2018 to January 2023 were included. The preoperative baseline data were not significantly different (all P values > 0.05). Both groups showed improvements in liver function and hypersplenism-related parameters. Within 2 weeks after surgery, Group A had significantly greater WBC (5.54 ± 1.92 × 10^9/L) and PLT (65.80 ± 20.12 × 10^9/L) counts than Group B (WBC: 4.14 ± 1.96 × 10^9/L; PLT: 52.70 ± 14.78 × 10^9/L; P < 0.05), indicating better control of hypersplenism. At 2 months postintervention, Group A demonstrated more favourable improvements in postintervention splenic volume (reduced from 1045 ± 122.9 cm³ to 489.5 ± 84.93 cm³), portal vein diameter (from 1.51 ± 0.19 cm to 1.28 ± 0.13 cm), and portal vein flow velocity (increased from 17.70 ± 5.25 cm/s to 23.56 ± 6.40 cm/s) than Group B. Moreover, a 53.2% splenic volume reduction was noted in Group A, which was significantly greater than the 31.4% reduction in Group B. Additionally, Group A had fewer adverse reactions, with lower liver/gastrointestinal toxicity (χ²=4.242, P = 0.039) and fever severity (χ²= 4.805, P = 0.028).

Conclusions: This study suggests that using Revolution CT prior to splenic artery embolization provides an effective method for managing hypersplenism, enhancing liver function, and reducing the risk of complications.

Keywords: Hypersplenism; Liver cirrhosis; Partial Splenic embolization; Three-dimensional CT reconstruction.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Our study was approved by Ethics Committee of Panzhihua Central Hospital (pzhszxyyII-2021-14). Informed consent was obtained from all the participants. All methods were carried out in accordance with relevant guidelines and regulations. Competing interests: The authors declare no competing interests. Consent for publication: Not appliable.

Figures

Fig. 1
Fig. 1
Imaging manifestations. A-B Coronal and cross-sectional CT images of the spleen. C-D Vascular reconstructions by Revolution 3D CT. E-G DSA images of the spleen
Fig. 2
Fig. 2
Coronal and cross-sectional CT images of the spleen at different follow-up intervals (A-G)
See this image and copyright information in PMC

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