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. 2025 Jul 3;44(1):227.
doi: 10.1186/s41043-025-00924-0.

Novel anthropometric and lipid indices as predictors of chronic kidney disease: insights from a decade-long cohort study

Ali Rezaee #  1 , Susan Darroudi #  2 , Aida Yavari  3 , Vahid Mahdavizadeh  4 , Motahhareh Karimoddini  5 , Farzam Kamrani  6 , Reza Salehi Manzari  7 , Ali Shariatikia  8 , Habibollah Esmaily  9   10 , Majid Ghayour-Mobarhan  11   12   13 , Mohsen Moohebati  14   15   16
Affiliations

Novel anthropometric and lipid indices as predictors of chronic kidney disease: insights from a decade-long cohort study

Ali Rezaee et al. J Health Popul Nutr. .

Abstract

Aim: In recent years, some studies have suggested that obesity and hyperlipidemia play a crucial role in chronic kidney disease (CKD); however, more research is needed. This study investigated the predictive role of lipid profiles and anthropometric indices in the incidence of CKD.

Methods and materials: The study subjects were participants in the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD), a prospective cohort study that began in 2010. Demographic information, anthropometric indices including body weight (BW), waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-hip ratio (WHR), waist-height ratio (WHtR), body adiposity index (BAI), body roundness index (BRI), weight-adjusted waist index (WWI), A body shape index (ABSI), abdominal volume index (AVI), WC/height ratio, and hip/height ratio, as well as laboratory investigations (including lipid profile) were recorded. Development of CKD was determined in the follow-up visits ten years after the first visit.

Results: Out of the 6,935 patients (41% male), 3859 (55%) were diagnosed with CKD. After adjusting confounders including age, sex, marriage, job, education, and smoking, the analysis revealed that weight (RR = 1.010 (1.006-1.014), p < 0.001), HC (RR = 1.011 (1.005-1.017), p < 0.001), height (RR = 1.026 (1.018-1.034), p < 0.001), WWI (RR = 0.917 (0.869-0.967), p < 0.01), Arm/height (RR = 1.361 (1.109-1.671, p < 0.01), and demispan/ height (RR = 1.361 (1.109-1.671) p < 0.01) were independent predictors of CKD.

Conclusion: Anthropometric and lipid indices have the potential to identify individuals at higher risk of developing CKD. However, further research is necessary in this field.

Keywords: 10-year follow-up; AVI; CKD; Cohort study; Demispan.

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Conflict of interest statement

Declarations. Ethical approval and consent to participate: Informed consent was obtained from all subjects. Accordingly, the study protocol was validated by the Ethics Committee of the Mashhad University of Medical Sciences (MUMS) and the Institutional Review Board of Mashhad University Medical Center. This project is supported by Mashhad University of Medical Sciences. Funding number: 4030741 and ethical approval cod: IR.MUMS.IRH.REC.1403.133. Consent for publication: It is not applicable to the Consent of Image Publication for this manuscript. The figures were designed only in this manuscript for presenting the results of the current paper. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of study population
Fig. 2
Fig. 2
Main findings
See this image and copyright information in PMC

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