Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Jun 18:41:e02292.
doi: 10.1016/j.idcr.2025.e02292. eCollection 2025.

Crossing boundaries: E. coli meningitis as an uncommon complication of hemorrhoidectomy

Affiliations
Case Reports

Crossing boundaries: E. coli meningitis as an uncommon complication of hemorrhoidectomy

Zarif Kazi et al. IDCases. .

Abstract

Escherichia coli meningitis is a rare cause of meningitis in adults. Overall, mortality due to meningitis is improving, but remains high for gram negative bacteria. It often progresses rapidly, and even if treated appropriately, can lead to long-term complications. An emerging concern is bacterial resistance to the empiric antibiotic regimen used in meningitis. The effect of adjunct dexamethasone on reducing mortality or preventing complications remains inconclusive. Here, we discuss a case of severe E. coli meningitis in a 56-year-old woman after a hemorrhoidectomy, leading to brain herniation and cardiac arrest.

Keywords: Bacteremia; Delayed diagnosis; Escherichia coli; Hemorrhoidectomy complication; Meningitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Zarif Kazi reports article publishing charges was provided by Maimonides Medical Center. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Potential transmission pathway for meningitis from hemorrhoidectomy.

Similar articles

References

    1. Zhao W.D., Liu D.X., Wei J.Y., et al. Caspr1 is a host receptor for meningitis-causing Escherichia coli. Nat Commun. 2018;9(1):2296. doi: 10.1038/s41467-018-04637-3. - DOI - PMC - PubMed
    1. Khan N.A., Wang Y., Kim K.J., Chung J.W., Wass C.A., Kim K.S. Cytotoxic necrotizing factor-1 contributes to Escherichia coli K1 invasion of the central nervous system. J Biol Chem. 2002;277(18):15607–15612. doi: 10.1074/jbc.M112224200. - DOI - PubMed
    1. Zhu N., Liu W., Prakash A., Zhang C., Kim K.S. Targeting E. coli invasion of the blood–brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis. Cell Microbiol. 2020;22(10) doi: 10.1111/cmi.13231. - DOI - PubMed
    1. Wang X., Maruvada R., Morris A.J., et al. Sphingosine 1-phosphate activation of EGFR as a novel target for meningitic Escherichia coli penetration of the blood-brain barrier. PLoS Pathog. 2016;12(10) doi: 10.1371/journal.ppat.1005926. - DOI - PMC - PubMed
    1. Ibrahim A., Saleem N., Naseer F., Ahmed S., Munawar N., Nawaz R. From cytokines to chemokines: understanding inflammatory signaling in bacterial meningitis. Mol Immunol. 2024;173:117–126. doi: 10.1016/j.molimm.2024.07.004. - DOI - PubMed

Publication types

LinkOut - more resources