WNT2/2B double homologous knockout blocks lung development and formation in pigs

Shuangjie Tian^#^{1

2}, Ruojun Zong^#^{1

2}, Ying Zhang^#^{3

4}, Qiang Liu⁵, Lina Wang^{1

2}, Yanfang Wang⁶, Jianguo Zhao^{7

8

9

10}

Affiliations

¹ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. zhangy@ioz.ac.cn.
⁴ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. zhangy@ioz.ac.cn.
⁵ Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
⁶ Laboratory of Animal (Poultry) Genetics Breeding and Reproduction, Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. wangyanfang@caas.cn.
⁷ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. zhaojg@ioz.ac.cn.
⁸ University of Chinese Academy of Sciences, Beijing, 100049, China. zhaojg@ioz.ac.cn.
⁹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. zhaojg@ioz.ac.cn.
¹⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhaojg@ioz.ac.cn.

^# Contributed equally.

PMID: 40614013
DOI: 10.1007/s11427-024-2936-y

WNT2/2B double homologous knockout blocks lung development and formation in pigs

Shuangjie Tian et al. Sci China Life Sci. 2025.

. 2025 Jul 2.

doi: 10.1007/s11427-024-2936-y. Online ahead of print.

Authors

Shuangjie Tian^#^{1

2}, Ruojun Zong^#^{1

2}, Ying Zhang^#^{3

4}, Qiang Liu⁵, Lina Wang^{1

2}, Yanfang Wang⁶, Jianguo Zhao^{7

8

9

10}

Affiliations

¹ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. zhangy@ioz.ac.cn.
⁴ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. zhangy@ioz.ac.cn.
⁵ Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
⁶ Laboratory of Animal (Poultry) Genetics Breeding and Reproduction, Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. wangyanfang@caas.cn.
⁷ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. zhaojg@ioz.ac.cn.
⁸ University of Chinese Academy of Sciences, Beijing, 100049, China. zhaojg@ioz.ac.cn.
⁹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. zhaojg@ioz.ac.cn.
¹⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhaojg@ioz.ac.cn.

^# Contributed equally.

PMID: 40614013
DOI: 10.1007/s11427-024-2936-y

No abstract available

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Conflict of interest statement

Compliance and ethics. The authors declare that they have no conflict of interest. All experiments involving pigs were approved by the institutional animal care and use committee of the Institute of Zoology, Chinese Academy of Sciences (approval no. IOZ-IACUC-2024-208).

References

1. Ashrafi, A., Akter, Z., Modareszadeh, P., Modareszadeh, P., Berisha, E., Alemi, P.S., Chacon Castro, M.C., Deese, A.R., and Zhang, L. (2022). Current landscape of therapeutic resistance in lung cancer and promising strategies to overcome resistance. Cancers 14, 4562. - DOI - PubMed - PMC
1. Chen, Q., Fang, B., Wang, Y., Li, C., Li, X., Wang, R., Xiong, Q., Zhang, L., Jin, Y., Zhang, M., et al. (2018). Overexpressing dominant-negative FGFR2-IIIb impedes lung branching morphogenesis in pigs. J Genet Genomics 45, 147–154. - DOI - PubMed
1. Edgar, L., Pu, T., Porter, B., Aziz, J.M., La Pointe, C., Asthana, A., and Orlando, G. (2020). Regenerative medicine, organ bioengineering and transplantation. Br J Surg 107, 793–800. - DOI - PubMed
1. Goss, A.M., Tian, Y., Tsukiyama, T., Cohen, E.D., Zhou, D., Lu, M.M., Yamaguchi, T.P., and Morrisey, E.E. (2009). Wnt2/2b and β-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell 17, 290–298. - DOI - PubMed - PMC
1. Jia, H., Chang, Y., and Song, J. (2024). The pig as an optimal animal model for cardiovascular research. Lab Anim 53, 136–147. - DOI

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WNT2/2B double homologous knockout blocks lung development and formation in pigs

Affiliations

WNT2/2B double homologous knockout blocks lung development and formation in pigs

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Conflict of interest statement

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