Trends and future directions in chronic rhinosinusitis with nasal polyps: A bibliometric analysis

Abstract

Objectives: Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a complex inflammatory condition that significantly impairs patients' quality of life. Despite significant efforts to develop effective treatments, a comprehensive bibliometric analysis in this field is lacking. This study aims to identify key trends, influential publications, leading authors, and collaborative networks.

Methods: A bibliometric analysis was conducted on October 16, 2024, examining publications in the Web of Science Core Collection (WoSCC) database from 2004 to 2024. Data visualization and interpretation were performed using VOSviewer (version 1.6.20), CiteSpace (version 6.3.R1), and R 4.3.3.

Results: The analysis included 1,235 publications from 5,825 authors across 4,723 institutions in 222 countries. The United States led in publication volume, followed by China and Italy. Major institutional contributors included Capital Medical University and Sanofi. The International Forum of Allergy & Rhinology published the most articles, while the Journal of Allergy and Clinical Immunology had the highest citation count. Key authors identified were Bachert Claus and Gevaert Philippe. Keyword analysis revealed "asthma", "endoscopic sinus surgery", and "inflammation" as dominant themes, with burst analysis indicating growing interest in "humanization", "type 2 inflammation", "risk", "biologics", and "safety".

Conclusion: This bibliometric analysis underscores an increasing focus on biologic therapies, inflammation management, and endoscopic sinus surgery in CRSwNP research. Future investigations are likely to prioritize the long-term safety and cost-effectiveness of biologics, alongside advancements in precision medicine and surgical techniques.

Level of evidence: Level 1.

Keywords: Bibliometric analysis; Biologic therapy; Chronic rhinosinusitis with nasal polyps; Citation analysis; Endoscopic surgery.

Fig. 1

Flowchart depicting the literature screening process for studies on CRSwNP treatment.

Fig. 2

Overview and Trends in Publications on CRSwNP treatment from 2004 to 2024. (A) Number of Publications on CRSwNP treatment. (B) Annual Number of Publications on CRSwNP treatment.

Fig. 3

Global Research Distribution and Collaboration in CRSwNP Treatment. (A) Map displaying the distribution of publications by corresponding authors’ countries, differentiating between Single Country Publications (SCP) and Multi-Country Publications (MCP). (B) Collaboration map indicating inter-country cooperation, with node size representing publication count and link thickness reflecting co-authorship strength.

Fig. 4

Institutional Contributions and Collaborations in CRSwNP Treatment. (A) Chart of the top 10 institutions by article count and ranking, with circle size indicating publication volume and color depth denoting rank. (B) Institutional collaboration map, where nodes are institutions sized by publication count, and links represent co-authorship strength, colored to differentiate research clusters.

Fig. 5

Analysis of Journal Networks in CRSwNP Treatment Research. (A) Co-occurrence networks show thematic connections between journals based on citation patterns within articles. (B) Coupling networks illustrate intellectual linkages between journals through commonly cited references.

Fig. 6

Author collaboration network in CRSwNP treatment.

Fig. 7

Keyword Co-occurrence Network and Citation Burst Analysis in CRSwNP Treatment. (A) Keyword co-occurrence clustering analysis. (B) Keyword co-occurrence network analysis. (C) Citation Burst Analysis.