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Review
. 2025 Jul 5.
doi: 10.1111/epi.18523. Online ahead of print.

Tumor-related epilepsy in glioma: A multidisciplinary overview

Roberto Michelucci  1 , Giada Pauletto  2 , Antonio Silvani  3 , Elena Pasini  1 , Tamara Ius  4 , Matteo Martinoni  1 , Carlo Alberto Castioni  1 , Andrea Salmaggi  5 , Sofia Asioli  1   6 , Marta Maschio  7 , Giuseppe Minniti  8 , Enrico Franceschi  1   9 , Flavio Villani  10 , Roberta Rudà  11 , Eleonora Aronica  12 ; Italian Multidisciplinary Group for Tumor Epilepsy
Collaborators, Affiliations
Review

Tumor-related epilepsy in glioma: A multidisciplinary overview

Roberto Michelucci et al. Epilepsia. .

Abstract

Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor-related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an updated overview about the pathophysiological mechanisms and treatment options of TRE associated with gliomas, based on expert contributions belonging to different areas. By combining the most recent discoveries and expert opinions, this study seeks to provide useful advice for TRE management in glioma patients. To improve patient outcomes and quality of life, prospective, standardized, multicentric studies should be promoted to optimize TRE patient care and refine therapeutic approaches.

Keywords: antiseizure medications; cerebral tumors; chemotherapy; epilepsy; epilepsy surgery; radiotherapy.

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References

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