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. 2025 Jun;57(2):316-320.
doi: 10.3947/ic.2025.0040.

Genomic Analysis of Multidrug Resistant Enterobacter hormaechei Strain AH1-NIMR Isolated from a Neonate with Sepsis in Lagos, Nigeria

Abiodun Tola Seriki  1 , Chioma Obi  1 , Amusa Azeez Olashile  1 , Utibeima Udo Essiet  2 , Desmond Wemimo Akingboye  3 , Abraham Ajayi  2   4 , Tenny Obiageli Gladys Egwuatu  3 , Stella Smith  2   5
Affiliations

Genomic Analysis of Multidrug Resistant Enterobacter hormaechei Strain AH1-NIMR Isolated from a Neonate with Sepsis in Lagos, Nigeria

Abiodun Tola Seriki et al. Infect Chemother. 2025 Jun.

Abstract

Enterobacter hormaechei has emerged as a major bacterial pathogen implicated in neonatal sepsis, with several strains acquiring resistance to commonly used antibiotics. In this study, we provide the antibiotic resistance profile and genomic analysis of a multidrug-resistant E. hormaechei AH1-NIMR isolated from a neonate presenting with sepsis in a tertiary hospital in Lagos, Nigeria. E. hormaechei AH1-NIMR was resistant to ten of twelve antibiotics that were tested. Whole-genome sequencing and bioinformatics analysis revealed that the isolate harboured several antimicrobial resistance determinants, including plasmids IncHI2-1 and Col(pHAD28). Enhanced surveillance and screening for E. hormaechei in sepsis cases are recommended.

Keywords: Antibiotic resistance; Enterobacter hormaechei; Plasmid; Sepsis; Whole genome sequencing.

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Conflict of interest statement

No conflict of interest.

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