Evaluation of Bleeding Disorders in the Newborn

Abstract

Neonatal bleeding disorders may present a diagnostic challenge to the pediatric clinician. Isolated thrombocytopenia rarely presents as a hemorrhagic emergency. Appropriate laboratory testing with incorporation of time of presentation and disease state is crucial to formatting an appropriate differential diagnosis. Deficiencies of certain coagulation proteins coupled with multiple acquired risk factors and/or thrombocytopenia can result in a hemorrhagic emergency in the neonatal period.

Keywords: Factor XIII deficiency; Fetal and neonatal alloimmune thrombocytopenia; Hemophilia; Hemorrhagic disease of the newborn; Neonatal hemorrhage; Thrombocytopenia.