Cancer of the corpus uteri: A 2025 update

Martin Koskas^{1

2}, Emma J Crosbie^{3

4}, Lars Fokdal^{5

6}, W Glenn McCluggage⁷, Linda Mileshkin^{8

9}, David G Mutch¹⁰, Frédéric Amant^{11

12}

Affiliations

¹ Division of Gynecologic Oncology, Bichat University Hospital, Paris, France.
² Paris Cité University, Paris, France.
³ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
⁴ Gynecology Department, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
⁵ Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
⁶ Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
⁷ Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.
⁸ Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
⁹ Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
¹⁰ Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
¹¹ Division of Gynecologic Oncology, UZ Leuven, Leuven, Belgium.
¹² Gynecologic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

PMID: 40622006
PMCID: PMC12411821
DOI: 10.1002/ijgo.70326

Review

Cancer of the corpus uteri: A 2025 update

Martin Koskas et al. Int J Gynaecol Obstet. 2025 Sep.

. 2025 Sep;171 Suppl 1(Suppl 1):60-77.

doi: 10.1002/ijgo.70326. Epub 2025 Jul 7.

Authors

Martin Koskas^{1

2}, Emma J Crosbie^{3

4}, Lars Fokdal^{5

6}, W Glenn McCluggage⁷, Linda Mileshkin^{8

9}, David G Mutch¹⁰, Frédéric Amant^{11

12}

Affiliations

¹ Division of Gynecologic Oncology, Bichat University Hospital, Paris, France.
² Paris Cité University, Paris, France.
³ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
⁴ Gynecology Department, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
⁵ Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
⁶ Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
⁷ Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.
⁸ Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
⁹ Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
¹⁰ Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
¹¹ Division of Gynecologic Oncology, UZ Leuven, Leuven, Belgium.
¹² Gynecologic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

PMID: 40622006
PMCID: PMC12411821
DOI: 10.1002/ijgo.70326

Abstract

Endometrial cancer comprises a heterogeneous group of neoplasms. Its incidence is increasing, as is mortality from endometrial cancer. This article updates many aspects surrounding endometrial cancer, covering histopathology, staging, surgical and non-surgical management, follow-up, and management of recurrent disease.

Keywords: FIGO cancer report; chemotherapy; corpus uteri; endometrial cancer; gynecologic cancer; radiotherapy; surgery.

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Conflict of interest statement

EJC is supported by a National Institute for Health and Care Research (NIHR) Advanced Fellowship (NIHR300650) and the NIHR Manchester Biomedical Research Centre (NIHR203308). MK received payment from Intuitive for proctoring, consulting, and presentations.

References

1. Bosse T, Nout RA, McAlpine JN, et al. Molecular classification of grade 3 Endometrioid endometrial cancers identifies distinct prognostic subgroups. Am J Surg Pathol. 2018;42:561‐568. doi: 10.1097/PAS.0000000000001020 - DOI - PMC - PubMed
1. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983;15:10‐17. doi: 10.1016/0090-8258(83)90111-7 - DOI - PubMed
1. Herrington CS, WHO Classification of Tumours Editorial Board , eds. Female Genital Tumours. WHO Classification of Tumours, 5th Edition, Volume 4. International Agency for Research on Cancer; 2020.
1. Gilks CB, Oliva E, Soslow RA. Poor interobserver reproducibility in the diagnosis of high‐grade endometrial carcinoma. Am J Surg Pathol. 2013;37:874‐881. doi: 10.1097/PAS.0b013e31827f576a - DOI - PubMed
1. Amant F, Cadron I, Fuso L, et al. Endometrial carcinosarcomas have a different prognosis and pattern of spread compared to high‐risk epithelial endometrial cancer. Gynecol Oncol. 2005;98:274‐280. doi: 10.1016/j.ygyno.2005.04.027 - DOI - PubMed

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Cancer of the corpus uteri: A 2025 update

Affiliations

Cancer of the corpus uteri: A 2025 update

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources