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. 2025 Jul 7;52(1):679.
doi: 10.1007/s11033-025-10765-z.

Mechanism of hydroxychloroquine in the treatment of obstetric antiphospholipid syndrome by inhibiting NETs-induced trophoblast pyroptosis

Jiayue Liu  1 , Mingyang Xu  1 , Di Shen  2   3 , Xietong Wang  4   5
Affiliations

Mechanism of hydroxychloroquine in the treatment of obstetric antiphospholipid syndrome by inhibiting NETs-induced trophoblast pyroptosis

Jiayue Liu et al. Mol Biol Rep. .
No abstract available

Keywords: Hydroxychloroquine; MAPK/NF-κB signaling; Neutrophil extracellular traps; Obstetric antiphospholipid syndrome; Oxidative stress.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Informed consent Statement and Institutional Review Board Statement: The content of the study involving patients/participants strictly complied with the World Medical Association Helsinki Declaration guidelines, and all patients/participants participated in the study voluntarily and informed consent was given. The related human study was approved by the Ethics Committee of the Provincial Hospital Affiliated to Shandong University (Approval NO.2021-011,17(th), January, 2021). The animal experiments were strictly performed in accordance with ARRIVE guidelines and the U.K. Animals (Scientific Procedures) Act, 1986, as well as related guidelines and China’s Experimental Animal Welfare Ethical Review Guidelines. The Ethics Committee of Shandong Provincial Hospital affiliated to Shandong First Medical University approved this study (NO. NSFC 2023 − 201).

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