Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025:2950:107-117.
doi: 10.1007/978-1-0716-4674-8_8.

Enterovirus Meningitis

Alfonso J Rodriguez-Morales  1   2 , Andrea G Rodriguez-Morales  3
Affiliations
Review

Enterovirus Meningitis

Alfonso J Rodriguez-Morales et al. Methods Mol Biol. 2025.

Abstract

Enterovirus meningitis is a leading cause of viral meningitis worldwide, predominantly affecting children and immunocompromised individuals. Enteroviruses, transmitted via fecal-oral and respiratory routes, cause seasonal outbreaks, straining healthcare systems. While typically self-limiting, severe cases can lead to encephalitis and neurological complications. Diagnosis relies on the polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) to distinguish it from bacterial meningitis. With no specific antiviral treatment available, supportive care remains essential, emphasizing the need for improved surveillance, prevention strategies, and vaccine development.

Keywords: Clinical; Enterovirus; Epidemiology; Global; Meningitis.

PubMed Disclaimer

References

    1. Baggen J, Thibaut HJ, Strating J, van Kuppeveld FJM (2018) The life cycle of non-polio enteroviruses and how to target it. Nat Rev Microbiol 16:368–381 - PubMed - DOI
    1. Fang Y, Wang C, Wang C, Yang R, Bai P, Zhang XY et al (2021) Antiviral peptides targeting the helicase activity of enterovirus nonstructural protein 2C. J Virol 95
    1. Lai JK, Sam IC, Chan YF (2016) The Autophagic machinery in enterovirus infection. Viruses 8
    1. Ding S, Liang TJ (2020) Is SARS-CoV-2 also an enteric pathogen with potential fecal-Oral transmission? A COVID-19 Virological and clinical review. Gastroenterology 159:53–61 - PubMed - DOI
    1. Wells AI, Coyne CB (2019) Enteroviruses: a gut-wrenching game of entry, detection, and evasion. Viruses 11

MeSH terms

LinkOut - more resources