Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025:1476:107-119.
doi: 10.1007/978-3-031-85340-1_5.

The C-Type Lectin Receptors

Kasturi Ganguly  1 , Taruna Madan  2
Affiliations
Review

The C-Type Lectin Receptors

Kasturi Ganguly et al. Adv Exp Med Biol. 2025.

Abstract

C-type lectins (CTLs) form a broad and diverse protein superfamily with the ability to identify a wide array of ligands with their characteristic C-type lectin-like domains (CTLDs), thus governing a broad spectrum of physiological functions. CTLD-containing proteins (CTLDcps) are now classified into 17 groups based on their phylogeny and overall domain organization. While much research has centered on the role of C-type lectins in innate and adaptive antimicrobial immune responses, their significance extends further. They are increasingly acknowledged for their significant involvement in cancer biology. It has been evident that the CLR signaling can wield dual effects akin to a double-edged sword across various microbial or oncogenic scenarios. Consequently, the therapeutic potential of both agonists and antagonists targeting CLR signaling is now surfacing as innovative strategies. The growing body of evidence highlighting the indispensable role of C-type lectin receptors (CTLR) in numerous biological processes underscores the necessity for a deeper comprehension of their functional capabilities in both immune defense and disease contexts.

Keywords: CLRs; CTLD; Cancer immunology; Innate immunity; Microbial immunity.

PubMed Disclaimer

References

    1. Alaeddine, M., Prat, M., Poinsot, V., Gouazé-Andersson, V., Authier, H., Meunier, E., Lefèvre, L., Alric, C., Dardenne, C., & Bernad, J. (2019). IL13-mediated dectin-1 and mannose receptor overexpression promotes macrophage antitumor activities through recognition of sialylated tumor cells. Cancer Immunology Research, 7, 321–334. - PubMed - DOI
    1. Albeituni, S. H., Ding, C., Liu, M., Hu, X., Luo, F., Kloecker, G., Bousamra, M., Zhang, H., & Yan, J. (2016). Yeast-derived particulate β-glucan treatment subverts the suppression of myeloid-derived suppressor cells (MDSC) by inducing polymorphonuclear MDSC apoptosis and monocytic MDSC differentiation to APC in cancer. Journal of Immunology, 196, 2167–2180. - DOI
    1. Bayraktar, R., & Calin, G. A. (2019). The interaction between two worlds: microRNAs and Toll-like receptors. Frontiers in Immunology, 10, 1053. - PubMed - PMC - DOI
    1. Behler-Janbeck, F., Takano, T., Maus, R., Stolper, J., Jonigk, D., Tort Tarrés, M., Fuehner, T., Prasse, A., Welte, T., Timmer, M. S. M., Stocker, B. L., Nakanishi, Y., Miyamoto, T., Yamasaki, S., & Maus, U. A. (2016). C-type lectin Mincle recognizes glucosyl-diacylglycerol of Streptococcus pneumoniae and plays a protective role in pneumococcal pneumonia. PLoS Pathogens, 12, 1. - DOI
    1. Boily-Larouche, G., Milev, M. P., Zijenah, L. S., Labbé, A. C., Zannou, D. M., Humphrey, J. H., Ward, B. J., Poudrier, J., Mouland, A. J., Cohen, É. A., & Roger, M. (2012). Naturally-occurring genetic variants in human DC-SIGN increase HIV-1 capture, cell-transfer and risk of mother-to-child transmission. PLoS One, 7, e40706. - PubMed - PMC - DOI

Substances

LinkOut - more resources