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Review
. 2025:1476:121-146.
doi: 10.1007/978-3-031-85340-1_6.

Collectins and Ficolins

Hajra Gupta  1 , Ann Mary Joseph  2 , Mughair Abdul Aziz  3 , Faryal Saeed  3 , Rekha Kumari  4 , Khaled Masmoudi  3 , Uday Kishore  2   5 , Taruna Madan  6
Affiliations
Review

Collectins and Ficolins

Hajra Gupta et al. Adv Exp Med Biol. 2025.

Abstract

Protein-carbohydrate interactions are utilized by the immune system for several defense activities. Collectins and ficolins have a key role in maintaining the balance of surfactants in the lungs and supporting the immune system in the lungs, respectively. This chapter provides an extensive description of two soluble pattern recognition receptors (PRRs), collectins and ficolins. It covers their structure, specificity for binding to certain ligands, biological functions along with initiating immune response by various mechanisms, their genetic characteristics, associations with various diseases, and their potential for use in therapy and diagnosis. The potential of collectins as diagnostic markers and therapeutic agents in diverse malignancies for their antitumorigenic effects has also been investigated. These findings have greatly enhanced our understanding of the innate immune system's previously overlooked specificity and effectiveness.

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References

    1. Ali, Y. M., Kenawy, H. I., Muhammad, A., et al. (2013). Human L-ficolin, a recognition molecule of the lectin activation pathway of complement, activates complement by binding to pneumolysin, the major toxin of Streptococcus pneumoniae. PLoS One, 8, e82583. https://doi.org/10.1371/journal.pone.0082583 - DOI - PubMed - PMC
    1. Al-Qahtani, A. A., Murugaiah, V., Bashir, H. A., et al. (2019). Full-length human surfactant protein A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity. Immunobiology, 224, 408–418. https://doi.org/10.1016/j.imbio.2019.02.006 - DOI - PubMed
    1. Amatya, S., Ye, M., Yang, L., et al. (2021). Single nucleotide polymorphisms interactions of the surfactant protein genes associated with respiratory distress syndrome susceptibility in preterm infants. Frontiers in Pediatrics, 9.
    1. Atkinson, A. P. M., Cedzynski, M., Szemraj, J., et al. (2004). L-ficolin in children with recurrent respiratory infections. Clinical and Experimental Immunology, 138, 517–520. https://doi.org/10.1111/j.1365-2249.2004.02634.x - DOI - PubMed - PMC
    1. Axford, J. S. (2012). Glycobiology and medicine. Springer.

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