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. 2025 Jul 1;28(4):606-608.
doi: 10.4103/aian.aian_747_24. Epub 2025 Jul 7.

Cerebral Chromoblastomycosis: A Unique Presentation of Dematiaceous Fungal Infection in an Immunocompromised Patient

Norton Stephen  1 , Soundarya Ravi  2 , Srinivas Bheemanathi Hanuman  2 , Vir Singh Negi  3 , Madhavan Sasidharan Gopalakrishnan  4
Affiliations

Cerebral Chromoblastomycosis: A Unique Presentation of Dematiaceous Fungal Infection in an Immunocompromised Patient

Norton Stephen et al. Ann Indian Acad Neurol. .
No abstract available

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
CECT (a) and serial slices of cMRI axial view T1 post-contrast images of the brain (b-d) show multiple ring-enhancing lesions in the right parietal, callosal, and pericallosal regions. CECT: Contrast-enhanced computed tomography, cMRI: Contrast magnetic resonance imaging
Figure 2
Figure 2
(a and b) The section shows well-formed epithelioid granulomas surrounded by lymphocytes, along with golden-brown pigmented, thick-walled fungal structures called Medlar bodies, as highlighted by black arrows (H and E; a- 200×, b- 400×). (c) Reactive gliosis in the brain parenchyma (H and E, 400×). (d and e) Sclerotic bodies highlighted by PAS stain and GMS stain (400×). (f) Sclerotic bodies highlighted by Masson-Fontana stain (200×). GMS: Gömöri’s methenamine silver, H and E: hematoxylin and eosin, PAS: periodic acid Schiff
Figure 3
Figure 3
Image of follow-up MRI (FLAIR) after 1 year revealed encephalomalacia with gliotic changes in the right cerebral hemisphere and resolution of the previously observed ring-enhancing lesions. FLAIR: fluid-attenuated inversion recovery, MRI: magnetic resonance imaging
See this image and copyright information in PMC

References

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