Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 7.
doi: 10.1097/RLU.0000000000006000. Online ahead of print.

Sarcoidosis on 18F-FDG PET/CT: Typical and Atypical Imaging Patterns

Raza Abbas Mahdi  1 , Vinisha Gunasekaran  1 , Tejasvini Singhal  1 , Harmandeep Singh  1 , Rajender Kumar  1 , Harpreet Singh  1 , Sahajal Dhooria  2 , Aastha Takkar  3 , Bhagwant Rai Mittal  1
Affiliations

Sarcoidosis on 18F-FDG PET/CT: Typical and Atypical Imaging Patterns

Raza Abbas Mahdi et al. Clin Nucl Med. .

Abstract

Sarcoidosis is a multisystem granulomatous inflammatory disease that typically involves the lungs and lymph nodes, but can involve any organ in the body, including (but not limited to) the liver, spleen, myocardium, and nervous system, leading to diverse clinical presentations and imaging findings. We hereby present a pictorial review of typical and atypical 18F-FDG PET/CT findings in histopathologically confirmed sarcoidosis patients with varied clinical presentations.

Keywords: bone marrow; nervous system; positron emission tomography computed tomography; sarcoidosis; spleen.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

    1. Ebert EC, Kierson M, Hagspiel KD. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol. 2008;103:3184–3192.
    1. Warshauer DM, Molina PL, Hamman SM, et al. Nodular sarcoidosis of the liver and spleen: analysis of 32 cases. Radiol. 1995;195:757–762.
    1. Birnie DH, Kandolin R, Nery PB, et al. Cardiac manifestations of sarcoidosis: diagnosis and management. Eur Heart J. 2017;38:2663–2670.
    1. Orii M, Hirata K, Tanimoto T, et al. The comparison of cardiac magnetic resonance imaging and F-fluoro-2-deoxyglucose positron emission tomography manifestations, and regional response to corticosteroid therapy in newly diagnosed cardiac sarcoidosis with complete heart block. Heart Rhythm. 2015;12:2477–2485.
    1. Atterton-Evans V, Turner J, Vivanti A, et al. Variances of dietary preparation for suppression of physiological 18F-FDG myocardial uptake in the presence of cardiac sarcoidosis: a systematic review. J Nucl Cardiol. 2020;27:481–489.

LinkOut - more resources