Survival rates and prognostic factors of 118 sinonasal sarcomas among adolescents and adults: a national database REFCOR study

Charles-Henri Hassan¹, Mélodie Kérimian², Caroline Even³, Antoine Moya-Plana³, Benjamin Verillaud⁴, Olivier Malard⁵, Justin Michel⁶, Valentin Favier⁷, Geoffrey Mortuaire⁸, Sylvain Morinière⁹, Bertrand Baujat¹⁰, Cécile Rumeau¹¹, Sebastien Vergez¹², Christian Righini¹³, Vincent Patron¹⁴, Charles Dupin¹⁵, Adam Loffler¹⁶, Antoine Bénard¹⁶, Laurence Digue¹⁷, Juliette Thariat¹⁸, Ludovic de Gabory¹⁹

Affiliations

¹ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Bordeaux, Bordeaux, France; Univ. Bordeaux, 33000, France.
² Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Bordeaux, Bordeaux, France.
³ Department of Otorhinolaryngology - Head and Neck Surgery, Gustave Roussy Cancer Center, Villejuif, France.
⁴ Department of Otorhinolaryngology - Head and Neck Surgery, Lariboisière University Hospital, Paris, France.
⁵ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Nantes, Nantes, France.
⁶ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Marseille, AP-HM Marseille, France.
⁷ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Montpellier, Montpellier, France.
⁸ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Lille, Lille, France.
⁹ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Tours, Tours, France.
¹⁰ Department of Otolaryngology-Head and Neck Surgery, Hopital Tenon, AP-HP, Sorbonne University, 75020, Paris, France.
¹¹ Department of Otorhinolaryngology, Université de Lorraine, CHRU Nancy, Service ORL, F-54000, Nancy, France.
¹² Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Toulouse, Toulouse, France.
¹³ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Grenoble, Grenoble, France.
¹⁴ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Caen, Caen, France.
¹⁵ Department of Oncology and Radiotherapy, Hôpital Haut-Lévêque, University Hospital of Bordeaux, avenue Magellan, Pessac, 33600, France.
¹⁶ Pôle de Santé Publique, Clinical Epidemiology Unit (USMR), F-33000, Bordeaux, France.
¹⁷ Department of Medical Oncology, University Hospital of Bordeaux, Bordeaux, France.
¹⁸ Comprehensive Cancer Centre Francois Baclesse, Department of Radiation Oncology, 3, avenue du Général Harris, 14000, Caen, France.
¹⁹ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Bordeaux, Bordeaux, France; Univ. Bordeaux, 33000, France. Electronic address: ludovic.de-gabory@chu-bordeaux.fr.

PMID: 40623344
DOI: 10.1016/j.ejso.2025.110247

Observational Study

Survival rates and prognostic factors of 118 sinonasal sarcomas among adolescents and adults: a national database REFCOR study

Charles-Henri Hassan et al. Eur J Surg Oncol. 2025 Sep.

. 2025 Sep;51(9):110247.

doi: 10.1016/j.ejso.2025.110247. Epub 2025 Jun 21.

Authors

Affiliations

¹ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Bordeaux, Bordeaux, France; Univ. Bordeaux, 33000, France.
² Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Bordeaux, Bordeaux, France.
³ Department of Otorhinolaryngology - Head and Neck Surgery, Gustave Roussy Cancer Center, Villejuif, France.
⁴ Department of Otorhinolaryngology - Head and Neck Surgery, Lariboisière University Hospital, Paris, France.
⁵ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Nantes, Nantes, France.
⁶ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Marseille, AP-HM Marseille, France.
⁷ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Montpellier, Montpellier, France.
⁸ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Lille, Lille, France.
⁹ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Tours, Tours, France.
¹⁰ Department of Otolaryngology-Head and Neck Surgery, Hopital Tenon, AP-HP, Sorbonne University, 75020, Paris, France.
¹¹ Department of Otorhinolaryngology, Université de Lorraine, CHRU Nancy, Service ORL, F-54000, Nancy, France.
¹² Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Toulouse, Toulouse, France.
¹³ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Grenoble, Grenoble, France.
¹⁴ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Caen, Caen, France.
¹⁵ Department of Oncology and Radiotherapy, Hôpital Haut-Lévêque, University Hospital of Bordeaux, avenue Magellan, Pessac, 33600, France.
¹⁶ Pôle de Santé Publique, Clinical Epidemiology Unit (USMR), F-33000, Bordeaux, France.
¹⁷ Department of Medical Oncology, University Hospital of Bordeaux, Bordeaux, France.
¹⁸ Comprehensive Cancer Centre Francois Baclesse, Department of Radiation Oncology, 3, avenue du Général Harris, 14000, Caen, France.
¹⁹ Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Bordeaux, Bordeaux, France; Univ. Bordeaux, 33000, France. Electronic address: ludovic.de-gabory@chu-bordeaux.fr.

PMID: 40623344
DOI: 10.1016/j.ejso.2025.110247

Abstract

Introduction: Sinonasal sarcomas are a heterogeneous group of rare tumors that are poorly documented and whose prognostic factors are not clearly established.

Material and methods: This was a retrospective multicenter observational study using the national REFCOR database to analyze the characteristics, management and prognostic factors of patients with sinonasal sarcomas among adolescents and adults. Overall survival and disease-free survival were assessed. The influence of age, gender, TNM classification, histological subtype, grade and treatment modality was calculated using Log-Rank tests and Cox proportional hazard models for multivariate analyses.

Results: 118 cases of sinonasal sarcomas were analyzed between 2010 and 2020. Median age was 50 years. Four histological subtypes predominated: rhabdomyosarcoma (21.2 %), chondrosarcoma (19.5 %), osteosarcoma (14.4 %) and biphenotypic sarcoma (9.3 %). Overall survival rates at 1, 3 and 5 years were respectively 99 %, 81.2 % and 68.8 %, and disease-free survival rates 96 %, 73.5 % and 58.3 %. Overall and disease-free survival of sinonasal sarcomas were significantly different by age (p < 0.001), gender (p < 0.001), histological subtype (p = 0.00062, with rhabdomyosarcomas and biphenotypic sarcomas being the most and least aggressive types, respectively), lymph node status (p = 0.05 and p < 0.0001), metastatic status (p = 0.004 and p < 10^-4), multimodal treatment protocol (p < 10^-4) including surgical resection (p < 10^-4). Surgery by endoscopic endonasal approaches yielded similar or better outcomes compared to open surgery.

Conclusion: Age, histological subtype, N+ and M+ status at diagnosis and therapeutic management influenced survival in sinonasal sarcomas. Survival rates varied widely according to histological subtype, and not all sarcomas have a poor prognosis.

Keywords: Endonasal endoscopic surgery; Paranasal cancer; REFCOR; Sarcoma; Sinonasal cancer.

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Conflict of interest statement

Declaration of competing interest The author declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Survival rates and prognostic factors of 118 sinonasal sarcomas among adolescents and adults: a national database REFCOR study

Affiliations

Survival rates and prognostic factors of 118 sinonasal sarcomas among adolescents and adults: a national database REFCOR study

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical