Disability and social cognition in euthymic patients with bipolar disorder
- PMID: 40624504
- PMCID: PMC12235995
- DOI: 10.1186/s12888-025-07119-1
Disability and social cognition in euthymic patients with bipolar disorder
Abstract
Background: Cognitive performance is known to influence the functional level of psychiatric disorders in both the short and long term. This study aims to examine disability, social cognition, and the clinical and sociodemographic variables affecting both in individuals diagnosed with bipolar disorder (BD) during the euthymic phase.
Methods: This cross-sectional study included 62 euthymic patients diagnosed with BD who attended the Mood Disorders Outpatient Clinic of the Psychiatry Department and agreed to participate. Data collection involved a sociodemographic information form, the Reading the Mind in the Eyes Test (RMET) and the Basic Empathy Scale (BES) to assess social cognition, and the World Health Organization Disability Assessment Schedule 2.0 (WHODAS-2) to evaluate disability.
Results: A significant positive correlation was identified between RMET scores and educational level (r = 0.320, p < 0.05). Regression analysis revealed that age (β=-0.284; p = 0.025) and social support(β=-0.310; p = 0.008) had a significant negative impact on WHODAS-2 total scores, whereas having a first episode of depression compared to a first episode of mania had a significant positive impact on WHODAS-2 total scores (β = 0.281; p = 0.025).
Conclusion: The findings suggest that the onset of BD with a depressive episode and the lack of social support may be associated with disability even in the euthymic phase. The significant negative association between age and disability implies that increased awareness through psychoeducation and the development of appropriate coping strategies may contribute to reduced disability in later life. These results highlight the importance of early intervention and supportive factors in the management of BD.
Keywords: Bipolar disorder; Disability; Social cognition; Theory of mind.
© 2025. The Author(s).
Conflict of interest statement
Declarations. Ethics approval and consent to participate: The methods of this study continued by the Helsinki Declaration. The study protocol was approved by the Ankara Etlik City Hospital-Scientific Research Evaluation and Ethics Committee(2024 − 859, date:25.09.2024). Informed consent was obtained from all participants. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests.
Similar articles
-
A review on the impact of cognitive dysfunction on social, occupational, and general functional outcomes in bipolar disorder.Bipolar Disord. 2015 Dec;17 Suppl 2:41-55. doi: 10.1111/bdi.12341. Bipolar Disord. 2015. PMID: 26688289
-
Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial.Health Technol Assess. 2025 May;29(21):1-216. doi: 10.3310/HBFC1953. Health Technol Assess. 2025. PMID: 40455248 Free PMC article. Clinical Trial.
-
Deficits of social cognition in bipolar disorder: Systematic review and meta-analysis.Bipolar Disord. 2022 Mar;24(2):137-148. doi: 10.1111/bdi.13163. Epub 2021 Dec 8. Bipolar Disord. 2022. PMID: 34825440
-
Reduced mitochondrial respiratory capacity in patients with acute episodes of bipolar disorder: Could bipolar disorder be a state-dependent mitochondrial disease?Acta Psychiatr Scand. 2024 Jan;149(1):52-64. doi: 10.1111/acps.13635. Epub 2023 Nov 29. Acta Psychiatr Scand. 2024. PMID: 38030136
-
The Black Book of Psychotropic Dosing and Monitoring.Psychopharmacol Bull. 2024 Jul 8;54(3):8-59. Psychopharmacol Bull. 2024. PMID: 38993656 Free PMC article. Review.
References
-
- López AG, Ezquiaga E, de Dios C, Agud JL, Soler B. Diagnostic delay and differences by sex and clinical subtype in a cohort of outpatients with bipolar disorder. Revista De Psiquiatria Y Salud Mental. 2010;3(3):79–89. - PubMed
-
- Vieta E, Iria Grande M, Berk. Boris birmaher, Eduard Vieta. Bipolar Disorder Lancet. 2016;387:1561–72. - PubMed
-
- Sanchez-Moreno J, Martinez-Aran A, Tabarés-Seisdedos R, Torrent C, Vieta E, Ayuso-Mateos J. Functioning Disabil Bipolar Disorder: Extensive Rev Psychother Psychosom. 2009;78(5):285–97. - PubMed
-
- Reinares M, Papachristou E, Harvey P, Bonnín CM, Sánchez-Moreno J, Torrent C, et al. Towards a clinical staging for bipolar disorder: defining patient subtypes based on functional outcome. J Affect Disord. 2013;144(1–2):65–71. - PubMed
-
- Pope M, Dudley R, Scott J. Determinants of social functioning in bipolar disorder. Bipolar Disord. 2007;9(1-2):38–44. - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Medical