Do women need a change in dose of prescription drugs with onset of menopause? Time to find out

Iris E C Sommer¹, Bodyl A Brand², Tanja R Zijp³, Marian J E Mourits⁴, Daan J Touw³

Affiliations

¹ Center for Clinical Neuroscience and Cognition and Department of Psychiatry, University Medical Centre Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands. i.e.c.sommer@umcg.nl.
² Center for Clinical Neuroscience and Cognition and Department of Psychiatry, University Medical Centre Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands.
³ Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands.
⁴ Department of Gynaecological Oncology, Rijks Universiteit Groningen (RUG), University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.

PMID: 40624672
PMCID: PMC12236021
DOI: 10.1186/s12916-025-04253-1

Do women need a change in dose of prescription drugs with onset of menopause? Time to find out

Iris E C Sommer et al. BMC Med. 2025.

. 2025 Jul 7;23(1):411.

doi: 10.1186/s12916-025-04253-1.

Authors

Iris E C Sommer¹, Bodyl A Brand², Tanja R Zijp³, Marian J E Mourits⁴, Daan J Touw³

Affiliations

¹ Center for Clinical Neuroscience and Cognition and Department of Psychiatry, University Medical Centre Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands. i.e.c.sommer@umcg.nl.
² Center for Clinical Neuroscience and Cognition and Department of Psychiatry, University Medical Centre Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands.
³ Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands.
⁴ Department of Gynaecological Oncology, Rijks Universiteit Groningen (RUG), University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.

PMID: 40624672
PMCID: PMC12236021
DOI: 10.1186/s12916-025-04253-1

No abstract available

Keywords: Enzymatic activity; Estrogen; Menopause; Metabolism; Pharmacokinetics.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

References

1. Madla CM, Gavins FKH, Merchant HA, Orlu M, Murdan S, Basit AW. Let’s talk about sex: Differences in drug therapy in males and females. Adv Drug Deliv Rev. 2021;175: 113804. - PubMed
1. Sommer IE, Brand BA, Stuijt CCM, Touw DJ. Sex differences need to be considered when treating women with psychotropic drugs. World Psychiatry. 2024;23(1):151-152.12. - PMC - PubMed
1. Lemmens HJ, Burm AG, Hennis PJ, Gladines MP, Bovill JG. Influence of age on the pharmacokinetics of alfentanil. Gender dependence Clin Pharmacokinet. 1990;19(5):416–22. - PubMed
1. Fleishaker JC, Pearson LK, Pearson PG, Wienkers LC, Hopkins NK, Peters GR. Hormonal effects on tirilazad clearance in women: assessment of the role of CYP3A. J Clin Pharmacol. 1999;39(3):260–7. - PubMed
1. Zijp T. Optimising tacrolimus treatment in solid organ transplant recipients: Bioanalysis, clinical variability, and monitoring. [Thesis fully internal (DIV), University of Groningen]. University of Groningen. 2024. 10.33612/diss.1069757148.

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Do women need a change in dose of prescription drugs with onset of menopause? Time to find out

Affiliations

Do women need a change in dose of prescription drugs with onset of menopause? Time to find out

Authors

Affiliations

Conflict of interest statement

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