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Clinical Trial
. 2025 Jul 1;27(7):euaf144.
doi: 10.1093/europace/euaf144.

Termination of atrial arrhythmia and restoration of sinus rhythm during pulsed field ablation with a pentaspline catheter in patients with persistent atrial fibrillation

Massimo Moltrasio  1 , Saverio Iacopino  2 , Francesco Solimene  3   4 , Stefano Bianchi  5 , Marco Schiavone  1 , Sakis Themistoclakis  6 , Antonio Rossillo  7 , Matteo Bertini  8 , Davide Zirolia  9 , Mario Volpicelli  10 , Gianluca Zingarini  11 , Antonio Dello Russo  4   12 , Maurizio Malacrida  13 , Giulio Zucchelli  14 , Claudio Tondo  1   15
Affiliations
Clinical Trial

Termination of atrial arrhythmia and restoration of sinus rhythm during pulsed field ablation with a pentaspline catheter in patients with persistent atrial fibrillation

Massimo Moltrasio et al. Europace. .

Abstract

Advanced TecHnologies For SuccEssful AblatioN of AF in Clinical Practice (ATHENA). URL: http://clinicaltrials.gov/Identifier: NCT05617456.

Keywords: Atrial fibrillation; Cellular electroporation; Persistent AF; Pulsed field ablation; Sinus rhythm restoration.

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Conflict of interest statement

Conflict of interest: M.S. received speaker’s honoraria from Boston Scientific. M.Ma.. is an employee of Boston Scientific. C.T. is a member of Boston Scientific advisory board. The other authors have no conflicts of interest to declare that are relevant to the content of this article. Final approval of manuscript: all authors.

Figures

Figure 1
Figure 1
(A) Flow diagram summarizing the rhythm outcomes of 335 patients with persistent atrial fibrillation (persAF) undergoing pulsed field ablation (PFA). Patients were grouped based on their rhythm at the beginning and end of the procedure. A total of 257 patients (76.7%) began the procedure in AF and subsequently achieved termination of atrial arrhythmia and sinus rhythm restoration (TASR). Of these, 172 (66.9%) required electrical cardioversion (ECV), while 85 (33.1%) achieved TASR directly through PFA energy delivery without ECV. (B) Kaplan–Meier curve showing freedom from AF recurrence at 1-year follow-up in patients who achieved TASR with or without ECV. There was a non-significant trend towards lower recurrence in the group that achieved TASR without ECV (HR = 0.55, 95% CI: 0.29–1.04, P = 0.0657). (C) Kaplan–Meier curve showing freedom from any atrial arrhythmia recurrence at 1-year follow-up in patients who achieved TASR with or without ECV. A similar trend was observed, favouring patients who restored sinus rhythm without ECV (HR = 0.58, 95% CI: 0.33–1.03, P = 0.0634).
See this image and copyright information in PMC

References

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