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. 2025 Jun 8;14(3):344-349.
doi: 10.1007/s13691-025-00779-6. eCollection 2025 Jul.

Definitive chemoradiotherapy for pulmonary epithelial-myoepithelial carcinoma

Keijiro Yamauchi  1 , Masashi Yokoyama  1 , Kayo Ueda  2 , Riiko Komuta  1 , Hidetaka Tanabe  1 , So Takata  1 , Takafumi Yanase  1 , Yuki Hosono  1 , Shingo Satoh  1 , Naoko Morishita  1 , Hideo Mori  2 , Hidekazu Suzuki  1
Affiliations

Definitive chemoradiotherapy for pulmonary epithelial-myoepithelial carcinoma

Keijiro Yamauchi et al. Int Cancer Conf J. .

Abstract

Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is a rare subtype of salivary gland tumor that is generally considered a low-grade malignancy and is treated with surgical resection. Here, we report a case of P-EMC treated with definitive chemoradiotherapy. A 68-year-old man developed P-EMC with high-grade features, a Ki-67 labeling index of 60%, and rapidly progressing disease. The patient received concurrent chemoradiotherapy with carboplatin and paclitaxel, which resulted in a significant tumor size reduction. The patient is currently alive 9 months after completing chemoradiotherapy without disease recurrence. This case suggests that platinum-based chemoradiotherapy is a viable therapeutic option for locally advanced, unresectable P-EMCs.

Keywords: Chemoradiotherapy; Epithelial-myoepithelial carcinoma; Lung cancer; Pulmonary epithelial-myoepithelial carcinoma; Salivary gland tumor.

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Conflict of interest statement

Conflict of interestThe authors declare that there are no known conflicts of interest.

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