Durable Responses With Front-Line Rituximab in Autoimmune Cytopenias Associated With Indolent B-Cell Clones

Yoann Zadro¹, Amélie Lusque², Héloïse Rey³, Pierre Cougoul¹, Jérémie Dion¹, Julie Graveleau⁴, Fanny Lemarié⁵, Lenaïg Le Clech⁵, Corentin Orvain⁶, Paul Albert Domnariu⁷, Clément Gourguechon⁸, Étienne Crickx⁹, Kamel Laribi¹⁰, Delphine Gobert¹¹, Léonce Adjoumani¹², Émilie Berthoux¹³, Alban Deroux¹⁴, Marie Durel¹⁵, Mikael Ebbo¹⁶, Jonathan Farhi¹⁷, Sébastien Humbert¹⁸, Vincent Jachiet¹¹, Joséphine Thomazeau¹⁹, Brice Castel²⁰, Clément Begey²¹, Jean-Baptiste Rieu²², Samuel Deshayes²³, Mathilde Devaux²⁴, Isabelle Durieu²⁵, Martin Gauthier²⁶, Marion Loirat²⁷, Étienne Rivière²⁸, Jean-Francois Viallard²⁸, Nihal Martis²⁹, Pierre-Yves Jeandel²⁹, Jérôme Paillassa¹⁷, Guillaume Denis³⁰, Sondess Hadj-Khelifa³¹, Christian Lavigne⁶, François Lifermann³², Emmanuel Andrès³³, Charles Dumontet³⁴, Vincent Grobost³⁵, Gaétan Sauvetre³⁶, Arsène Mekinian¹¹, Marc Michel⁹, Bertrand Godeau⁹, Loïc Ysebaert³⁷, Guillaume Moulis³⁸, Thibault Comont¹

Affiliations

¹ Department of Internal Medicine, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
² Department of Biostatistics, IUCT-Oncopole, Oncopole Claudius Regaud, Toulouse, France.
³ Department of Clinical Research, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
⁴ Department of Internal Medicine, Nantes University Hospital, Nantes University, Nantes, France.
⁵ Department of Internal Medicine, Infectious and Blood Diseases, Cornouaille Quimper-Concarneau Hospital, Quimper, France.
⁶ Maladies du Sang, Angers University Hospital, Angers University, Angers, France.
⁷ Department of Internal Medicine, Kremlin-Bicêtre University Hospital, Le Kremlin-Bicêtre, France.
⁸ Department of Internal Medicine, Amiens University Hospital, Amiens University, Amiens, France.
⁹ Department of Internal Medicine, Henri-Mondor University Hospital, Paris-Est Créteil University, Assistance Publique-Hôpitaux de Paris, Créteil, France.
¹⁰ Department of Hematology, Le Mans Hospital, Le Mans, France.
¹¹ Department of Internal Medicine, Saint-Antoine University Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
¹² Department of Hematology, Avignon Hospital, Avignon, France.
¹³ Department of Internal Medicine, Saint-Joseph and Saint-Luc Hospital, Lyon, France.
¹⁴ Department of Internal Medicine, Grenoble University Hospital, Grenoble University, La Tronche, France.
¹⁵ Department of Internal Medicine, Robert Schuman Hospital-UNEOS, Metz, France.
¹⁶ Department of Internal Medicine, Marseille University Hospital, Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
¹⁷ Department of Hematology, Angers University Hospital, Angers University, Angers, France.
¹⁸ Department of Hematology, University Hospital of Besançon, Besançon, France.
¹⁹ Department of Internal Medicine, Ariège Valleys Hospital, Saint-Jean-de-Verges, France.
²⁰ Department of Internal Medicine, Bigorre Hospital, Tarbes, France.
²¹ Department of Oncology, University Hospital of Besançon, Besançon University, Besançon, France.
²² Hematology Laboratory, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
²³ Department of Internal Medicine, Caen University Hospital, Caen University, Caen, France.
²⁴ Department of Internal Medicine, Poissy-Saint-Germain-en-Laye Hospital, Saint-Germain-en-Laye, France.
²⁵ Department of Internal Medicine, Lyon University Hospital, Lyon University, Pierre-Bénite, France.
²⁶ Department of Hematology, Jean Rougier Hospital, Cahors, France.
²⁷ Department of Hematology, Saint-Nazaire Hospital, Saint-Nazaire, France.
²⁸ Department of Internal Medicine, Bordeaux University Hospital, Bordeaux University, Pessac, France.
²⁹ Department of Internal Medicine, Nice University Hospital, Côte d'Azur University, Nice, France.
³⁰ Department of Hematology, Rochefort Hospital, Rochefort, France.
³¹ Department of Hematology, Auch Hospital, Auch, France.
³² Department of Internal Medicine, Dax Hospital, Dax, France.
³³ Department of Internal Medicine, Strasbourg University Hospital, Strasbourg University, Strasbourg, France.
³⁴ Department of Hematology, Lyon University Hospital, Lyon University, Lyon, France.
³⁵ Department of Internal Medicine, Clermont-Ferrand University Hospital, Clermont-Ferrand University, Clermond-Ferrand, France.
³⁶ Department of Internal Medicine, Rouen University Hospital, Rouen University, Rouen, France.
³⁷ Department of Hematology, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
³⁸ Department of Internal Medicine, Purpan-Toulouse University Hospital, Toulouse University, Toulouse, France.

PMID: 40626616
DOI: 10.1002/ajh.27754

Durable Responses With Front-Line Rituximab in Autoimmune Cytopenias Associated With Indolent B-Cell Clones

Yoann Zadro et al. Am J Hematol. 2025 Sep.

. 2025 Sep;100(9):1670-1674.

doi: 10.1002/ajh.27754. Epub 2025 Jul 8.

Authors

Affiliations

¹ Department of Internal Medicine, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
² Department of Biostatistics, IUCT-Oncopole, Oncopole Claudius Regaud, Toulouse, France.
³ Department of Clinical Research, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
⁴ Department of Internal Medicine, Nantes University Hospital, Nantes University, Nantes, France.
⁵ Department of Internal Medicine, Infectious and Blood Diseases, Cornouaille Quimper-Concarneau Hospital, Quimper, France.
⁶ Maladies du Sang, Angers University Hospital, Angers University, Angers, France.
⁷ Department of Internal Medicine, Kremlin-Bicêtre University Hospital, Le Kremlin-Bicêtre, France.
⁸ Department of Internal Medicine, Amiens University Hospital, Amiens University, Amiens, France.
⁹ Department of Internal Medicine, Henri-Mondor University Hospital, Paris-Est Créteil University, Assistance Publique-Hôpitaux de Paris, Créteil, France.
¹⁰ Department of Hematology, Le Mans Hospital, Le Mans, France.
¹¹ Department of Internal Medicine, Saint-Antoine University Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
¹² Department of Hematology, Avignon Hospital, Avignon, France.
¹³ Department of Internal Medicine, Saint-Joseph and Saint-Luc Hospital, Lyon, France.
¹⁴ Department of Internal Medicine, Grenoble University Hospital, Grenoble University, La Tronche, France.
¹⁵ Department of Internal Medicine, Robert Schuman Hospital-UNEOS, Metz, France.
¹⁶ Department of Internal Medicine, Marseille University Hospital, Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
¹⁷ Department of Hematology, Angers University Hospital, Angers University, Angers, France.
¹⁸ Department of Hematology, University Hospital of Besançon, Besançon, France.
¹⁹ Department of Internal Medicine, Ariège Valleys Hospital, Saint-Jean-de-Verges, France.
²⁰ Department of Internal Medicine, Bigorre Hospital, Tarbes, France.
²¹ Department of Oncology, University Hospital of Besançon, Besançon University, Besançon, France.
²² Hematology Laboratory, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
²³ Department of Internal Medicine, Caen University Hospital, Caen University, Caen, France.
²⁴ Department of Internal Medicine, Poissy-Saint-Germain-en-Laye Hospital, Saint-Germain-en-Laye, France.
²⁵ Department of Internal Medicine, Lyon University Hospital, Lyon University, Pierre-Bénite, France.
²⁶ Department of Hematology, Jean Rougier Hospital, Cahors, France.
²⁷ Department of Hematology, Saint-Nazaire Hospital, Saint-Nazaire, France.
²⁸ Department of Internal Medicine, Bordeaux University Hospital, Bordeaux University, Pessac, France.
²⁹ Department of Internal Medicine, Nice University Hospital, Côte d'Azur University, Nice, France.
³⁰ Department of Hematology, Rochefort Hospital, Rochefort, France.
³¹ Department of Hematology, Auch Hospital, Auch, France.
³² Department of Internal Medicine, Dax Hospital, Dax, France.
³³ Department of Internal Medicine, Strasbourg University Hospital, Strasbourg University, Strasbourg, France.
³⁴ Department of Hematology, Lyon University Hospital, Lyon University, Lyon, France.
³⁵ Department of Internal Medicine, Clermont-Ferrand University Hospital, Clermont-Ferrand University, Clermond-Ferrand, France.
³⁶ Department of Internal Medicine, Rouen University Hospital, Rouen University, Rouen, France.
³⁷ Department of Hematology, IUCT-Oncopole-Toulouse University Hospital, Toulouse University, Toulouse, France.
³⁸ Department of Internal Medicine, Purpan-Toulouse University Hospital, Toulouse University, Toulouse, France.

PMID: 40626616
DOI: 10.1002/ajh.27754

Abstract

Durable responses with front-line rituximab in autoimmune cytopenias associated with indolent B-Cell clones.

Keywords: B‐cell lymphoma; autoimmune hemolytic anemia; chronic lymphocytic leukemia; immune thrombocytopenia; rituximab.

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Durable Responses With Front-Line Rituximab in Autoimmune Cytopenias Associated With Indolent B-Cell Clones

Affiliations

Durable Responses With Front-Line Rituximab in Autoimmune Cytopenias Associated With Indolent B-Cell Clones

Authors

Affiliations

Abstract

Publication types

MeSH terms

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LinkOut - more resources

Full Text Sources

Medical