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Editorial
. 2025 Jul 8:14:e107777.
doi: 10.7554/eLife.107777.

Returning aging cells to productivity

Rachana S Vaidya  1 , Simon Y Tang  2
Affiliations
Editorial

Returning aging cells to productivity

Rachana S Vaidya et al. Elife. .

Abstract

Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.

Keywords: cell biology; human; inflammation; intervertebral disc; platelet-derived growth factors (PDGFs); senescence.

PubMed Disclaimer

Conflict of interest statement

RV, ST No competing interests declared

Figures

Figure 1.
Figure 1.. Using platelet-derived growth factors (PDGFs) to target cellular senescence and low back pain.
(Top): Cellular senescence in the cells of the nucleus pulposus (NP) and the annulus fibrosus (AF) contributes to intervertebral disc (IVD) degeneration and low back pain. Senescent IVD cells (left) display mitochondrial damage, oxidative stress, a senescence-associated secretory phenotype (SASP), SA-β-gal activity, nuclear membrane dysfunction, and cell cycle arrest. These changes promote disc matrix breakdown and pain. (Bottom): Zhang et al. isolated NP cells (circles) and AF cells (elongated shapes) from degenerated human IVDs and treated them with isoforms of recombinant human PDGF (PDGF-AB and PDGF-BB). Treatment with PDGF reduced various markers of senescence (downward green arrows), while increasing production of PDGF receptor alpha (PDGFRA) and restarting the cell cycle. Healthy cells are shown in blue; senescent cells are shown in red.
See this image and copyright information in PMC

Comment on

  • doi: 10.7554/eLife.103073

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