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[Preprint]. 2025 Jul 5:2025.07.03.25330855.
doi: 10.1101/2025.07.03.25330855.

Cardiac Troponin T Elevation Predicts Mortality in Hospitalized COVID-19 Patients

Katelyn A Bruno  1   2 , R Scott Wright  3 , Joshua Culberson  1   2 , Mikolaj A Wieczorek  4 , David O Hodge  4 , Patrick W Johnson  4 , Yomary A Jimenez  2 , Emily R Whelan  1 , Jose M Malavet  1 , Kathryn F Larson  3 , Jonathon W Senefeld  5   6 , Chad C Wiggins  5   7 , Stephen A Klassen  8 , Jacob Ricci  2 , Taimur Sher  9 , Rickey E Carter  4 , Michael J Joyner  5 , DeLisa Fairweather  1 , Allan S Jaffe  3   10
Affiliations

Cardiac Troponin T Elevation Predicts Mortality in Hospitalized COVID-19 Patients

Katelyn A Bruno et al. medRxiv. .

Abstract

Objective: To evaluate if cardiac troponin values predict poor outcomes in COVID-19 patients across the range of patients of different sex and age.

Methods: We examined high-sensitivity cardiac troponin T (hs-cTnT) levels in 1,050 severely ill hospitalized COVID-19 patients who had hs-cTnT data available and participated in the Expanded Access Program for convalescent plasma study during the first wave (April-August 2020) of the COVID-19 pandemic.

Results: We observed a continuous relationship between hs-cTnT levels and mortality in hospitalized males and females with COVID-19. This finding was present regardless of sex or age.

Conclusion: These data indicate the prognostic ability of hs-cTnT to predict mortality in hospitalized COVID-19 patients across all relevant patient groups.

Clinical trials registration number: NCT04338360.

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Figures

Figure 1.
Figure 1.. 30-day mortality rates by hs-cTnT groups for males and females.
The percentages are visualized with the lower and upper limits for each group. Sex-specific cut-offs are 10 ng/L for females (red) and 15 ng/L for males (blue). The 99th percentile threshold is the ESC guidelines conjoint threshold.
See this image and copyright information in PMC

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