Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 1:25:474-484.
doi: 10.1016/j.xjon.2025.03.014. eCollection 2025 Jun.

Extracorporeal membrane oxygenation as a bridge to lung transplant for patients with interstitial lung disease: An international survey study

Anil J Trindade  1 , Whitney D Gannon  1 , John W Stokes  2 , Emily A Vail  3 , Cara Agerstrand  4 , Mauer Biscotti 3rd  5 , Sarah L Bloom  1 , Caitlin T Demarest  2 , Matthew Bacchetta  6   7 , Konrad Hoetzenecker  2
Affiliations

Extracorporeal membrane oxygenation as a bridge to lung transplant for patients with interstitial lung disease: An international survey study

Anil J Trindade et al. JTCVS Open. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest.

Figures

None
A global survey study to assess pragmatic center-specific practices of ECMO-BTT for ILD.
Figure 1
Figure 1
Determinants of eligibility for extracorporeal membrane oxygenation as bridge to transplantation (ECMO-BTT) at the transplant center level. Box-and-whisker plots represent the median and interquartile range (IQR) of scores ranking the importance of specific clinical criteria for ECMO-BTT candidate selection for patients with interstitial lung disease listed for transplant, from least (1) to most (5) important on a Likert scale. Median scores for the most important variables were as follows: frailty, 5 (IQR, 4-5); consciousness, 5 (IQR, 3-5); age, 4 (IQR, 4-5); mobility, 4 (IQR, 3-5), and retransplantation candidate, 4 (IQR, 3-5). Survey responses were received from 69 transplant centers.
Figure 2
Figure 2
Considerations for timing of extracorporeal membrane oxygenation as bridge to transplantation (ECMO-BTT) initiation. Box-and-whisker plots represent the median and interquartile range (IQR) of scores ranking the importance of physiologic parameters informing the timing of ECMO-BTT initiation for patients with interstitial lung disease listed for lung transplantation from least important (1) to most important (5) on a Likert scale. Median values for each parameter were as follows: hypoxemia, 5 (IQR, 4-5); hypercapnia, 4 (IQR, 4-5); work of breathing, 4 (IQR, 3-4); decline in mobility, 3 (IQR, 2-4); worsened right ventricular function, 4 (IQR 3-5). Survey responses were received from 69 transplant centers.
Figure E1
Figure E1
Locations of the survey respondents. The 69 centers from which we received survey responses included 40 (58%) located in North America, 22 (32%) in Europe, 3 (4%) in Asia, 2 (3%) in the Middle East, and 2 (3%) in Australia.
Figure E2
Figure E2
Center-specific age limitations of extracorporeal membrane oxygenation as bridge to lung transplantation (ECMO-BTT). Survey responses from 69 transplant centers regarding the existence of local age limitations for ECMO-BTT are shown. Thirty-seven centers (54%) reported having an age limit for ECMO-BTT eligibility, including 16 (43%) in the 60- to 64-year range, 11 (30%) in the 65- to 69-year range, 5 (14%) in the 70- to 74-year range, 3 (8%) of <50 years, and 2 (5%) in to 59 years.
Figure E3
Figure E3
Center-specific preferred initial ECMO-BTT configuration. Survey responses from 69 transplant centers regarding the preferred initial ECMO-BTT configuration for interstitial lung disease patients without significant World Health Organization Group 3 pulmonary hypertension are shown. Sixty-five centers (94%) reported that venovenous ECMO was the preferred initial configuration, with 41 centers favoring 2-site cannulation and 24 centers preferring a single-site, dual-lumen approach. Two centers (3%) preferred upper body venoarterial ECMO as the initial configuration, while another 2 centers (3%) used an OxyRVAD (right ventricular assist device + oxygenator) circuit initially. ECMO, Extracorporeal membrane oxygenation; BTT, bridge to lung transplantation.
See this image and copyright information in PMC

References

    1. Tipograf Y., Salna M., Minko E., et al. Outcomes of extracorporeal membrane oxygenation as a bridge to lung transplantation. Ann Thorac Surg. 2019;107(5):1456–1463. doi: 10.1016/j.athoracsur.2019.01.032. - DOI - PubMed
    1. Hayanga J.W.A., Dhamija A., Hayanga H.K., Fugett J., Toker A. Commentary: burning your bridges. Semin Thorac Cardiovasc Surg. Winter 2020;32(4):786–787. doi: 10.1053/j.semtcvs.2020.06.009. - DOI - PMC - PubMed
    1. Sharma A., Minh Duc N.T., Luu Lam Thang T., et al. A consensus-based checklist for reporting of survey studies (CROSS) J Gen Intern Med. 2021;36(10):3179–3187. doi: 10.1007/s11606-021-06737-1. - DOI - PMC - PubMed
    1. Brasel K., Haider A., Haukoos J. Practical guide to survey research. JAMA Surg. 2020;155(4):351–352. doi: 10.1001/jamasurg.2019.4401. - DOI - PubMed
    1. Hartwig M., van Berkel V., Bharat A., et al. The American Association for Thoracic Surgery (AATS) 2022 Expert Consensus Document: the use of mechanical circulatory support in lung transplantation. J Thorac Cardiovasc Surg. 2023;165(1):301–326. doi: 10.1016/j.jtcvs.2022.06.024. - DOI - PubMed

LinkOut - more resources