Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Sep;36(9):2188-2195.
doi: 10.1111/jce.16781. Epub 2025 Jul 9.

Improvement in Mitral Regurgitation After Catheter Ablation of Premature Ventricular Complexes

Nithi Tokavanich  1 , Abiola Alaka  1 , Michael Tye  1 , Apurba Chakrabarti  1 , Sayhaan Goraya  2 , Mason Yoder  1 , Chaitanya Madamanchi  1 , Kelly Arps  1 , Muazzum Shah  1 , Amrish Deshmukh  1 , Michael Ghannam  1 , Ryan Cunnane  1 , Krit Jongnarangsin  1 , Thomas Crawford  1 , Aman Chugh  1 , Rakesh Latchamsetty  1 , Hakan Oral  1 , Fred Morady  1 , Frank Bogun  1 , Jackson J Liang  1
Affiliations

Improvement in Mitral Regurgitation After Catheter Ablation of Premature Ventricular Complexes

Nithi Tokavanich et al. J Cardiovasc Electrophysiol. 2025 Sep.

Abstract

Background: Frequent premature ventricular complexes (PVC) can lead to left ventricular (LV) dysfunction. Reduction of PVC burden can result in improvement of LV function. Whether successful PVC ablation can also result in improvement of mitral regurgitation (MR) in patients with frequent PVCs and MR remains unclear.

Objective: We aimed to evaluate the impact of PVC ablation on the degree of MR in patients with patients with frequent PVCs and MR.

Method: We retrospectively analyzed patients with MR and frequent PVCs who underwent PVC ablation from January 2015 to December 2024. Severity of MR was compared between pre- and post-PVC ablation to identify improvement of valvular regurgitation.

Results: A total of 47 patients were included in the study. All patients had at least mild MR (6 with mild MR, 17 mild-moderate MR, 19 moderate MR, 3 moderate-severe MR, and 2 severe MR). The mean PVC burdens before versus after ablation were 23.5 ± 11% and 4 ± 4.1% (p = 0.02), respectively. Improvement (by ≥ 1 grade) of MR was seen in 30 of 47 (64%) patients after ablation. Among patients with > 80% PVC reduction after ablation, 19 of 29 (65.5%), 50%-80% PVC reduction, 9 of 13 (69%), and < 50% PVC reduction, 2 of 5 (40%) showed improvement of MR. All 5 of (100%) patients with greater than moderate MR demonstrated an improvement in MR severity after PVC ablation.

Conclusion: There appears to be a trend toward an MR improvement with reduction in PVC burden after successful PVC ablation.

Keywords: MR; PVC; mitral regurgitation; premature ventricular contraction; radiofrequency ablation.

PubMed Disclaimer

References

    1. R. Latchamsetty and F. Bogun, “Premature Ventricular Complex–Induced Cardiomyopathy,” JACC: Clinical Electrophysiology 5 (2019): 537–550.
    1. J. F. Huizar, K. Kaszala, J. Potfay, et al., “Left Ventricular Systolic Dysfunction Induced by Ventricular Ectopy,” Circulation Arrhythmia and electrophysiology 4 (2011): 543–549.
    1. J. G. Panizo and S. Barra, “Premature Ventricular Complex‐Induced Cardiomyopathy,” Arrhythmia & Electrophysiology Review 7 (2018): 128–134.
    1. L. E. de Groot‐de Laat, J. McGhie, B. Ren, R. Frowijn, F. B. Oei, and M. L. Geleijnse, “A Modified Echocardiographic Classification of Mitral Valve Regurgitation Mechanism: The Role of Three‐Dimensional Echocardiography,” Journal of Cardiovascular Imaging 27 (2019): 187–199.
    1. C. Mitchell, P. S. Rahko, L. A. Blauwet, et al., “Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations From the American Society of Echocardiography,” Journal of the American Society of Echocardiography 32 (2019): 1–64.

MeSH terms

LinkOut - more resources