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Multicenter Study
. 2025 May 1;57(3):159-165.
doi: 10.4103/ijp.ijp_744_23. Epub 2025 Jul 9.

Prescribing trends of fixed-dose combination of domperidone and proton-pump inhibitor across tertiary care centers in India, is the combination rational?

Ajay Kumar Shukla  1 , Sameer Uttamrao Khasbage  2 , Ratinder Jhaj  1 , Balakrishnan Sadasivam  1 , Jerin Jose Cherian  3 , Preeta Kaur Chugh  4 , C D Tripathi  5 , Chetna K Desai  6 , Prakruti Parth Patel  6 , Niyati A Trivedi  7 , Janki Chauhan  7 , Jayanthi Mathaiyan  8 , S Manikandan  8 , Ramasamy Raveendran  8 , Pooja Gupta  9 , Sandhya Kaustubh Kamat  10 , Raakhi Kaliprasad Tripathi  10 , Yashashri Shetty  10 , Suparna Chatterjee  11 , Debaleena Das  11 , Atiya R Faruqui  12 , Sujith J Chandy  13 , Harihar Dikshit  14 , Hitesh Mishra  14 , Sukalyan Saha Roy  14 , Rajiv Kumar  14 , Rupa Joshi  15 , Ajay Prakash  15 , Bikash Medhi  15 , Nilima Kshirsagar  3
Affiliations
Multicenter Study

Prescribing trends of fixed-dose combination of domperidone and proton-pump inhibitor across tertiary care centers in India, is the combination rational?

Ajay Kumar Shukla et al. Indian J Pharmacol. .

Abstract

Background: There have been concerns over the rationality of prescribing practices of fixed-dose combinations (FDCs) available in India. The FDC of domperidone and pantoprazole recently emerged as a top-selling product at Janaushadhi Kendras in India.

Methods: This cross-sectional study is a part of the prescription research which was conducted under the Indian Council of Medical Research (ICMR) Task Force Project on Rational Use of Drugs at 13 tertiary healthcare centers across the countries that were part of the ICMR-Rational Use of Medicine Centres Network. An assessment of rationality for prescribing practices of FDC of domperidone and proton-pump inhibitors (PPIs) was done based on the available guidelines and evidence from the literature.

Results: In this study, 8839 outpatient prescriptions were analyzed in which FDCs with domperidone and PPI were prescribed in 481 (5.44%) cases. The FDC containing domperidone + PPI was prescribed for nausea and vomiting in 10.81% of cases. The dose was not mentioned in 55% of prescriptions; the dose of domperidone up to 30 mg/day was mentioned in 42.41% of prescriptions and more than 30 mg/day in 2.28% of prescriptions. In 89.18% of cases, it was prescribed to patients under 60 years of age.

Conclusions: This study has shown a lack of rationality in the prescribing practices in FDC containing domperidone and PPI in terms of indications, dose, frequency, duration, and administration instructions.

Keywords: Domperidone; fixed-dose combinations; proton-pump inhibitors; rationality.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Diagnosis-wise prescription pattern of fixed-dose combination containing domperidone and proton-pump inhibitor. ICD-10 = International Classification of Diseases-10
Figure 2
Figure 2
Prescription pattern of domperidone alone and as fixed-dose combination. FDC = Fixed-dose combination, PPI = Proton-pump inhibitor
See this image and copyright information in PMC

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