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. 2025 Jul 10;393(2):198-200.
doi: 10.1056/NEJMc2504010.

Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018-2024

David Helekal  1 , Tatum D Mortimer  2 , Yonatan H Grad  1
Affiliations

Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018-2024

David Helekal et al. N Engl J Med. .
No abstract available

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Figures

Figure.
Figure.
Expansion of N. gonorrhoeae carrying the tetM resistance determinant. A. The estimated proportion of isolates carrying tetM in a national surveillance dataset of N. gonorrhoeae from 2018 through the first quarter of 2024. The black line represents the modeled median estimate from data from HHS regions 2–10 (no data were available for HHS region 1) and the grey area represents the 95% credible interval. B. The phylogenetic relationships among tetM-carrying N. gonorrhoeae isolates reported in the dataset (see Supplementary Appendix for the full phylogeny with the deep branches and isolates without tetM). The diamonds indicate the roots of the lineages of tetM carrying isolates, with blue indicating the major tetM lineage circulating in the US before 2020 and red the major lineages after 2020. The circles indicate N. gonorrhoeae specimens; blue denotes those isolated before 2020 and red those isolated after 2020. The annotation columns to the right of the phylogeny indicate the presence or absence of penA variants, mosaic penA 34 and the A501V mutation, that increase resistance to cephalosporins.
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