A Comparative Analysis of Subtyping Methodologies on Cross-sectional sMRI Data

Shirui Zhang¹, Baitong Zhang¹, Kun Zhao¹, Zhuangzhuang Li¹, Pan Wang², Dawei Wang³, Chengyuan Song⁴, Jie Lu⁵, Zengqiang Zhang⁶, Hongxiang Yao⁷, Tong Han⁸, Chunshui Yu⁹, Bo Zhou¹⁰, Ying Han^{11

12

13}, Xi Zhang¹⁰, Pindong Chen^{14

15}, Yong Liu^{16

17

18}; Alzheimer’s Disease Neuroimaging Initiative (ADNI), for the Multi-Center Alzheimer’s Disease Imaging (MCADI) Consortium

Affiliations

¹ School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
² Department of Neurology, Tianjin Huanhu Hospital, Tianjin, 300350, China.
³ Department of Radiology, Qilu Hospital of Shandong University, Ji'nan, 250012, China.
⁴ Department of Neurology, Qilu Hospital of Shandong University, Ji'nan, 250012, China.
⁵ Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
⁶ Branch of Chinese, PLA General Hospital, Sanya, 572013, China.
⁷ Department of Radiology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100039, China.
⁸ Department of Radiology, Tianjin Huanhu Hospital, Tianjin, 300350, China.
⁹ Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 300350, China.
¹⁰ Department of Neurology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100039, China.
¹¹ Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
¹² School of Biomedical Engineering, Hainan University, Haikou, 570228, China.
¹³ National Clinical Research Center for Geriatric Disorders, Beijing, 100730, China.
¹⁴ School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, 100876, China. pindong.chen@outlook.com.
¹⁵ Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. pindong.chen@outlook.com.
¹⁶ School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, 100876, China. yongliu@bupt.edu.cn.
¹⁷ Queen Mary School Hainan, Beijing University of Posts and Telecommunications, Hainan, 572423, China. yongliu@bupt.edu.cn.
¹⁸ Center for Inspur-BUPT, Beijing University of Posts and Telecommunications, Beijing, 100876, China. yongliu@bupt.edu.cn.

PMID: 40634761
PMCID: PMC12433415 (available on 2026-09-01)
DOI: 10.1007/s12264-025-01462-9

A Comparative Analysis of Subtyping Methodologies on Cross-sectional sMRI Data

Shirui Zhang et al. Neurosci Bull. 2025 Sep.

. 2025 Sep;41(9):1689-1695.

doi: 10.1007/s12264-025-01462-9. Epub 2025 Jul 9.

Authors

Affiliations

¹ School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
² Department of Neurology, Tianjin Huanhu Hospital, Tianjin, 300350, China.
³ Department of Radiology, Qilu Hospital of Shandong University, Ji'nan, 250012, China.
⁴ Department of Neurology, Qilu Hospital of Shandong University, Ji'nan, 250012, China.
⁵ Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
⁶ Branch of Chinese, PLA General Hospital, Sanya, 572013, China.
⁷ Department of Radiology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100039, China.
⁸ Department of Radiology, Tianjin Huanhu Hospital, Tianjin, 300350, China.
⁹ Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 300350, China.
¹⁰ Department of Neurology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100039, China.
¹¹ Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
¹² School of Biomedical Engineering, Hainan University, Haikou, 570228, China.
¹³ National Clinical Research Center for Geriatric Disorders, Beijing, 100730, China.
¹⁴ School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, 100876, China. pindong.chen@outlook.com.
¹⁵ Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. pindong.chen@outlook.com.
¹⁶ School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, 100876, China. yongliu@bupt.edu.cn.
¹⁷ Queen Mary School Hainan, Beijing University of Posts and Telecommunications, Hainan, 572423, China. yongliu@bupt.edu.cn.
¹⁸ Center for Inspur-BUPT, Beijing University of Posts and Telecommunications, Beijing, 100876, China. yongliu@bupt.edu.cn.

PMID: 40634761
PMCID: PMC12433415 (available on 2026-09-01)
DOI: 10.1007/s12264-025-01462-9

No abstract available

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Conflict of interest statement

Conflict of interest: The authors declare no conflicts of interest.

References

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A Comparative Analysis of Subtyping Methodologies on Cross-sectional sMRI Data

Affiliations

A Comparative Analysis of Subtyping Methodologies on Cross-sectional sMRI Data

Authors

Affiliations

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources