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Review
. 2022 Mar 10;1(1):65-71.
doi: 10.1016/j.iliver.2022.02.004. eCollection 2022 Mar.

The pathophysiological mechanism between hypopituitarism and nonalcoholic fatty liver disease

Xinhe Zhang  1 , Haoyu Tian  2 , Yiling Li  1
Affiliations
Review

The pathophysiological mechanism between hypopituitarism and nonalcoholic fatty liver disease

Xinhe Zhang et al. ILIVER. .

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common chronic metabolic liver disease worldwide. It is closely related to diseases of the cardiovascular system and chronic kidney disease. It can also occur secondary to many other diseases. Current research shows that patients with hypopituitarism have a high risk of developing NAFLD. After the adenohypophysis is dominated by hypothalamic hormones, hormones are secreted to act on the corresponding tissues or organs. It is characterized by a decrease in the thyroid hormone, cortisol, and growth hormone levels. In this review, we analyzed the mechanisms related to NAFLD through thyroid secretion, growth hormone secretion, sex hormone, and prolactin axes in patients with hypopituitarism, which will provide information and a theoretical basis for clinical diagnosis and treatment.

Keywords: Hypopituitarism; NAFLD; Pathophysiological mechanism.

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Figures

Fig. 1
Fig. 1
The hypothalamus–pituitary–gland axis.
Fig. 2
Fig. 2
The pathophysiological mechanism for hypopituitarism and nonalcoholic fatty liver disease.
See this image and copyright information in PMC

References

    1. Yeliosof O., Gangat M. Diagnosis and management of hypopituitarism. Curr Opin Pediatr. 2019;31(4):531–536. - PubMed
    1. Jasim S., Alahdab F., Ahmed A.T., et al. Mortality in adults with hypopituitarism: a systematic review and meta-analysis. Endocrine. 2017;56(1):33–42. - PubMed
    1. Heidelbaugh J.J. vol. 451. FP Essent; 2016. pp. 25–30. (Endocrinology Update: Hypopituitarism). - PubMed
    1. Perumpail B.J., Khan M.A., Yoo E.R., et al. Clinical epidemiology and disease burden of nonalcoholic fatty liver disease. World J Gastroenterol. 2017;23(47):8263–8276. - PMC - PubMed
    1. Friedman S.L., Neuschwander-Tetri B.A., Rinella M., et al. Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 2018;24(7):908–922. - PMC - PubMed

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