Bone regeneration using PRF, PRP and β-TCP in bone defects

Abstract

Bone regeneration using platelet-rich fibrin (PRF), platelet-rich plasma (PRP) and beta-tricalcium phosphate (β-TCP) in bone defects is of interest. PRF achieved the maximum bone fill (85%) during the 12 weeks assessment period while PRP and β-TCP reached 75% and 65% bone fill, respectively. Trabecular bone density proved superior in defects treated with PRF according to the histological findings (p < 0.05). The prolonged availability of growth factors from PRF resulted in better bone tissue formation. The biomaterial PRF demonstrates strong potential to become an effective solution for efficient bone healing in clinical medicine.

Keywords: Bone regeneration; beta-tricalcium phosphate (β-TCP); bone defects; osteogenesis; platelet-rich fibrin (PRF); platelet-rich plasma (PRP).