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. 2025 Jul 5:18:3767-3774.
doi: 10.2147/IJGM.S529946. eCollection 2025.

The Value of Myocardial Energy Expenditure in the Diagnosis of Cirrhotic Cardiomyopathy

Lei Zhang  1 , Kuopeng Liang  1 , Donghui Ji  1
Affiliations

The Value of Myocardial Energy Expenditure in the Diagnosis of Cirrhotic Cardiomyopathy

Lei Zhang et al. Int J Gen Med. .

Abstract

Objective: This study aimed to evaluate the diagnostic value of myocardial energy expenditure (MEE) in cirrhotic cardiomyopathy (CCM).

Methods: A cohort of 100 patients with cirrhosis were classified into a CCM group (34 cases) and a non-CMM group (66 cases) based on the 2020 CCM guidelines. Moreover, 30 healthy volunteers served as a control group. MEE and conventional echocardiographic parameters were measured, and intergroup differences were analyzed. MEE was measured by ultrasound and calculated by formula. Multivariate logistic regression was performed to determine the relationship between significant indicators and CCM. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic performance of MEE, echocardiographic parameters, and their combination (MEE + echocardiography) in diagnosing CCM.

Results: (1) Significant differences were observed in the left atrial volume index (LAVI), left ventricular ejection fraction (LVEF), Tei index(TI), early/late peak diastolic flow rate (E/A) ratio, and MEE among the three groups (P < 0.05). (2) Both LVEF and MEE were substantially correlated with CCM and identified as independent predictors (P < 0.05). (3) The ROC analysis revealed areas under the curve (AUCs) of 0.834 and 0.929, respectively, with a combined diagnostic AUC of 0.965 for MEE +LVEF.

Conclusion: MEE and LVEF are reliable predictive markers for CCM, with their combined assessment offering superior diagnostic accuracy.

Keywords: cirrhotic cardiomyopathy; echocardiography; liver cirrhosis; myocardial energy expenditure.

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Conflict of interest statement

The authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Receiver Operating Characteristic (ROC) curves for MEE, LVEF, and combined MEE+ LVEF in diagnosing CCM.
See this image and copyright information in PMC

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