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. 2025 Jul 8;13(7):e70629.
doi: 10.1002/ccr3.70629. eCollection 2025 Jul.

Rare Presentation of Adult-Onset Still's Disease Complicated by Acute Severe Hepatitis Refractory to Medical Treatment: A Case Report

Majed Ali  1 , Karam Karam  2 , Emanuel-Youssef Dib  1 , Elias Fiani  2
Affiliations

Rare Presentation of Adult-Onset Still's Disease Complicated by Acute Severe Hepatitis Refractory to Medical Treatment: A Case Report

Majed Ali et al. Clin Case Rep. .

Abstract

Managing adult-onset Still's disease complicated by severe hepatitis requires vigilant monitoring and adaptable therapeutic strategies. Standard treatments such as tocilizumab and rituximab can cause adverse reactions or lose efficacy. The interplay of systemic inflammation and liver involvement highlights the need for ongoing research to find effective, safe treatment alternatives.

Keywords: IL‐6 receptor inhibition; adult‐onset Still's disease; rituximab; severe hepatitis; tocilizumab.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Images of the patient's diffuse salmon‐colored rash upon presentation.
See this image and copyright information in PMC

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References

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