Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 13;4(1):100140.
doi: 10.1016/j.iliver.2024.100140. eCollection 2025 Mar.

Emerging role of natural bioactive compounds in navigating the future of liver disease

Neha Chaudhary  1 , Muhammad Arif  1 , Sheeba Shafi  2 , Shom Prakash Kushwaha  1 , Pushpendra Soni  1
Affiliations
Review

Emerging role of natural bioactive compounds in navigating the future of liver disease

Neha Chaudhary et al. ILIVER. .

Abstract

Liver diseases, including liver inflammation, fatty liver disease, cirrhosis, and hepatocellular carcinoma, represent significant global health challenges. Traditional treatments often emphasize symptom management, leading to increased interest in natural bioactive compounds for their potential therapeutic benefits. This review examines the role of natural bioactive compounds in managing hepatic disorders, with a particular focus on their mechanisms of action and supporting clinical evidence. Compounds such as curcumin, silymarin, resveratrol, triterpenoids, apigenin, and delphinidin derivatives have demonstrated promising hepatoprotective effects in preclinical studies, largely due to their anti-inflammatory, antioxidant, and anti-fibrotic properties. Nevertheless, further research is necessary to determine optimal dosing, safety profiles, and long-term effects. Understanding the mechanisms of action and therapeutic potential of these bioactive compounds may provide critical insights into their role in the treatment of hepatic diseases.

Keywords: Alcohol-associated hepatic disease; Autoimmune hepatitis; Hepatoprotective; Medicine-induced hepatic injury; Nonalcoholic fatty hepatic disease; Resveratrol; Viral hepatitis.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Causes of liver diseases and potential remedies with potent hepatoprotective medicinal plants.
Fig. 2
Fig. 2
Medicinal plants with hepatoprotective properties. (A) Aegle marmelos. (B) Silybum marianum. (C) Cynara scolymus. (D) Curcuma longa. (E) Taraxacum officinale. (F) Aloe vera. (G) Zingiber officinale. (H) Glycyrrhiza glabra. (I) Panax ginseng. (J) Alchornea cordifolia. (K) Cassia fistula. (L) Clitoria ternatea. (M) Ficus religiosa. (N) Ginkgo biloba. (O) Hypericum japonicum. (P) Phyllanthus niruri.
Fig. 3
Fig. 3
Natural bioactive compounds targeting liver disease.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Devarbhavi H., Asrani S.K., Arab J.P., et al. Global burden of liver disease: 2023 update. J Hepatol. 2023;79(2):516–537. doi: 10.1016/j.jhep.2023.03.017. - DOI - PubMed
    1. Dhillon A., Steadman R.H. Anesthesia and uncommon diseases. 6th ed. Elsevier; Amsterdam, The Netherlands: 2012. Liver diseases; pp. 162–214. - DOI
    1. Goldacre M.J., Wotton C.J., Yeates D., et al. Liver cirrhosis, other liver diseases, pancreatitis and subsequent cancer: record linkage study. Eur J Gastroenterol Hepatol. 2008;20(5):384–392. doi: 10.1097/MEG.0b013e3282f4489f. - DOI - PubMed
    1. Liu C.Y., Chen K.F., Chen P.J. Treatment of liver cancer. Cold Spring Harb Perspect Med. 2015;5(9):a021535. doi: 10.1101/cshperspect.a021535. - DOI - PMC - PubMed
    1. Zahid M., Arif M., Rahman M.A., et al. Hepatoprotective and antioxidant activities of Annona squamosa seed extract against alcohol-induced liver injury in Sprague Dawley rats. Drug Chem Toxicol. 2020;43(6):588–594. doi: 10.1080/01480545.2018.1517772. - DOI - PubMed

LinkOut - more resources